摘要
目的研究采用三联抗栓方案治疗冠心病合并房颤患者的临床效果。方法选取2017年5月至2019年5月本院收治的78例冠心病合并房颤患者,采用随机数字表法分为对照组和治疗组,每组39例。对照组采用华法林和阿司匹林两种药物联合方案进行治疗;治疗组采用华法林、阿司匹林、氯吡格雷3种药物联合方案进行治疗。对比两组患者药物治疗总有效率、不良反应情况、用药前后生活质量评分、心电图复常时间、患者临床症状消失时间、住院时间。结果治疗组患者治疗总有效率为92.3%,高于对照组的69.2%,差异有统计学意义(P<0.05);治疗组有2例患者发生药物不良反应,对照组中有8例患者发生药物不良反应,两组不良反应发生率比较差异有统计学意义(P<0.05);治疗后,治疗组患者生活质量评分改善幅度大于对照组(P<0.05);治疗组患者心电图复常时间、临床症状消失时间、住院时间短于对照组(P<0.05)。结论冠心病合并房颤患者采用华法林、阿司匹林、氯吡格雷三联抗栓方案实施治疗,可以迅速控制症状,恢复心电图表现,减少药物相关不良反应,缩短住院时间,大幅度改善生活质量,提高疾病治疗效果。
Objective To study the clinical effect of triple antithrombotic regimen in patients with coronary heart disease complicated with atrial fibrillation.Methods 78 patients with coronary heart disease and atrial fibrillation who were admitted to our hospital from May 2017 to May 2019 were selected,they were divided into control group and treatment group by random number table method,with 39 cases in each group.The control group was treated with a combination of warfarin and aspirin,the treatment group was treated with warfarin,aspirin and clopidogrel.The total effective rate of drug treatment,adverse drug reaction,quality of life score before and after medication,ECG recurrence time,time of clinical symptom disappearance,and hospitalization time were compared between the two groups.Results The total effective rate of treatment in the treatment group was 92.3%,which was higher than that 69.2%of the control group,the difference was statistically significant(P<0.05).There were 2 cases with adverse drug reactions,and 8 cases in the control group had adverse drug reactions,the difference was statistically significant(P<0.05).The improvement of patients'quality of life scores after treatment in the treatment group was greater than that of the control group(P<0.05).The patients'electrocardiogram recurrence time,clinical symptom disappearance time and hospitalization time in the treatment group were shorter than the control group(P<0.05).Conclusion Patients with coronary heart disease and atrial fibrillation treated with warfarin,aspirin and clopidogrel triple antithrombotic regimen can quickly control symptoms,restore ECG performance,reduce drug-related adverse reactions,shorten hospital stay,and greatly improve quality of life,and improve the effectiveness of disease treatment.
作者
杨辉建
张志霞
乐薇
Yang Huijian;Zhang Zhixia;LeWei(Internal Medicine,People's Hospital of Dongxiang District,Fuzhou City,Jiangxi Province,Fuzhou,Jiangxi,331800,China)
出处
《当代医学》
2020年第22期49-51,共3页
Contemporary Medicine
关键词
冠心病
房颤
华法林
阿司匹林
氯吡格雷
效果
Coronary heart disease
Atrial fibrillation
Warfarin
Aspirin
Clopidogrel
Effect
