摘要
目的观察桃红四物汤合涤痰汤治疗脑梗死急性期风痰瘀阻证患者的疗效,并探讨其对脑血流动力学以及血清脂蛋白A和同型半胱氨酸水平的影响。方法本研究纳入的62例急性脑梗死患者,按数字表法随机分为对照组和观察组各31例。对照组按指南采取常规治疗措施。观察组在对照组治疗基础上采用桃红四物汤合涤痰汤治疗,1剂/d,分早晚2次分服。两组连续治疗2周。比较两组患者的肢体运动功能、步行能力、风痰瘀阻证症状评分、临床疗效、国立卫生院神经功能缺损量表(NIHSS)评分、颈动脉内膜中层厚度(IMT)、脑血流动力学以及血清脂蛋白A和同型半胱氨酸水平。结果疗程结束后,观察组患者疗程结束后上下肢Fugl-Meyer运动量表(FMMS)评分显著高于对照组,步行能力、风痰瘀阻证症状(头晕目眩、痰多、舌质黯)、NIHSS评分以及IMT明显少于对照组(P<0.01);观察组的总有效率为93.55%(29/31),显著高于对照组为67.74%(21/31)(P<0.05);观察组患者疗程结束后大脑动脉血流平均流速(Vm)、最大峰值流速(Vs)明显高于对照组,血管阻力指数(RI)显著少于对照组(P<0.01);观察组患者疗程结束后血清脂蛋白A和同型半胱氨酸水平显著少于对照组(P<0.01)。结论桃红四物汤合涤痰汤治疗脑梗死急性期风痰瘀阻证疗效明显,且可改善患者的脑血流动力学以及下调血清脂蛋白A和同型半胱氨酸水平。
Objective To observe the efficacy of Taohong Siwu Decoction and Ditan Decoction on treating acute cerebral infarction patients with syndrome of wind-phlegm-stasis and investigate the effect on cerebral hemodynamics and serum levels of lipoprotein A and homocysteine.Method Sixty-two acute cerebral infarction patients in this study were randomly divided into the control group and the observation group according to the number table method.The control group received conventional treatment according to the guidelines.On the basis of the treatment in the control group,the observation group was treated with Taohong Siwu Decoction and Ditan Decoction(1 dose/d,taking in the morning and evening,twice a day).Both groups were treated for 2 weeks.Scores of limb motor function,walking ability,symptoms of syndrome of wind-phlegm-stasis,the clinical efficacy,score of National institutes of health neurological impairment scale(NIHSS),carotid endomedial media thickness(IMT),cerebral hemodynamics,and serum levels of lipoprotein A and homocysteine were compared between two groups.Results After treatment,the score of the upper and lower fugl-meyer exercise scale(FMMS)of the observation group was significantly higher than that of the control group,and scores of the walking ability,symptoms of wind-phlegm-stasis(dizziness,phlegm,dark tongue),and NIHSS and IMT of the observation group were significantly lower than those of the control group(P<0.01).The total effective rate in the observation group was 93.55%(29/31),significantly higher than that in the control group(67.74%,21/31)(P<0.05).After treatment,the mean cerebral artery blood flow velocity(Vm)and maximum peak flow velocity(Vs)in the observation group were significantly higher than those in the control group,and the vascular resistance index(RI)was significantly lower than that in the control group(P<0.01).Serum levels of lipoprotein A and homocysteine in the observation group were significantly lower than those in the control group after the treatment(P<0.01).Conclusion The efficacy of Taohong Siwu Decoction combined with Ditan Decoction on treating acute cerebral infarction patients with syndrome of wind-phlegm-stasis is significant and can improve cerebral hemodynamics and down-regulate serum levels of lipoprotein A and homocysteine.
作者
李存明
赵广峰
张秀芳
林紫薇
LI Cunming;ZHAO Guangfeng;ZHANG Xiufang;LIN Ziwei(Department of Traditional Chinese Medicine,Bozhou People’s Hospital,Bozhou 236800,Anhui,China;Geriatric Department,Bozhou People’s Hospital,Bozhou 236800,Anhui,China)
出处
《中华中医药学刊》
CAS
北大核心
2020年第6期152-155,共4页
Chinese Archives of Traditional Chinese Medicine
基金
安徽省重点研究和开发计划(1804h08020296)。
关键词
桃红四物汤
涤痰汤
脑梗死急性期
风痰瘀阻证
Taohong Siwu Decoction
Ditan Decoction
acute cerebral infarction
syndrome of wind-phlegm-stasis
