摘要
目的观察通心络胶囊辅助治疗对脑梗死气虚血瘀证患者肢体运动功能的疗效以及脑血流动力学和血清血管内皮生长因子(VEGF)水平的影响。方法66例脑梗死患者采用随机数字法分为对照组和观察组各33例。对照组指南予西医常规治疗。观察组在对照组治疗基础上采用通心络胶囊,口服,4粒/次,3次/d。两组连续治疗4周。比较两组肢体运动功能指标[Fugl-Meyer运动量表(FMMS)和步行能力]评分、气虚血瘀证症状评分、临床疗效、脑血流动力学指标[大脑动脉血流平均流速(Vm)、最大峰值流速(Vs)、血管阻力指数(RI)]以及血清血管内皮生长因子(VEGF)水平。结果治疗4周后,观察组患者的上下肢FMMS评分显著高于对照组,步行能力和气虚血瘀证症状(气短乏力、面色■白、自汗、便溏、舌质黯)评分显著低于对照组(P<0.01);观察组患者的总有效率为90.91%(30/33),显著高于对照组为69.70%(23/33)(P<0.05);观察组患者Vs、Vm、VEGF明显高于对照组,RI显著低于对照组(P<0.01)。结论在常规治疗基础上,通心络胶囊可进一步改善脑梗死气虚血瘀证患者的肢体运动功能,提高临床疗效,且可改善患者的脑血流动力学和VEGF水平。
Objective To observe the efficacy of Tongxinluo Capsule assisted treatment improving limb motor function in cerebral infarction patients with syndrome of Qi deficiency and blood stasis and its influence on cerebral hemodynamics and serum level of vascular endothelial growth factor(VEGF).Method A total of 66 cerebral infarction patients were randomly divided into the control group and the observation group with 33 cases in each by random number table.The control group was treated with routine western medicine.On the basis of treatment of the control group,the observation group was orally treated with Tongxinluo Capsules(4 capsules/time,three times a day).Both groups were treated for 4 weeks.Scores of limb movement function indexs[Fugl-Meyer scale(FMMS)and walking ability]and symptoms of syndrome of Qi deficiency and blood stasis,the efficacy,cerebral hemodynamic index[average cerebral artery blood flow velocity(Vm),maximum peak flow velocity(Vs),vascular resistance index(RI)]and serum level of VEGF were compared between two groups.Results:After 4 weeks treatment,the score of FMMS was obviously higher,while scores of walking ability and symptoms(shortness of breath,fatigue,white complexion,spontaneous perspiration,loose stools,tongue dark)of syndrome of Qi deficiency and blood stasis were lower than those of the control group(P<0.01).The total effective rate of the observation group(90.91%,30/33)was significantly higher than that of the control group(69.70%,23/33)(P<0.05).Vs,Vm and VEGF of the observation were significantly higher while RI was significantly lower than those of the control group(P<0.01).Conclusion On the basis of routine therapy,Tongxinluo Capsule can further improve the limb movement function of patients with cerebral infarction syndrome of Qi deficiency and blood stasis,increase the efficacy and improve the levels of cerebral hemodynamics and VEGF.
作者
陈建媚
韩丽雅
周帆
CHEN Jianmei;HAN Liya;ZHOU Fan(Neurology Department,Wenzhou Center Hospital,Wenzhou 325003,Zhejiang,China;Department of Neurology and Traditional Chinese Medicine,Wenzhou Central Hospital,Wenzhou 325003,Zhejiang,China)
出处
《中华中医药学刊》
CAS
北大核心
2020年第6期233-236,共4页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省卫生厅科研项目(2011KYA148)。
关键词
通心络胶囊
脑梗死
气虚血瘀证
脑血流动力学
血管生长相关因子
Tongxinluo Capsule
cerebral infarction
syndrome of Qi deficiency and blood stasis
cerebral hemodynamics
vascular endothelial growth factor
