摘要
目的评价疏肝化郁解毒汤对子宫颈癌术后化疗患者的治疗效果及对血清Th1/Th2水平的影响。方法选择2017年3月—2019年2月医院收治的子宫颈癌患者92例,依据随机对照法将患者分为治疗组和对照组,每组46例。对照组采用多西他赛加奥沙利铂,治疗组在化疗的同时,口服疏肝化郁解毒汤辅助治疗。4周为1个周期,共治疗3个周期。比较两组治疗前后中医症候积分、治疗疗效、治疗前后血清Th1/Th2相关因子水平、治疗前后细胞免疫指标T淋巴细胞亚群CD^+3、CD^+4、CD^+8、CD^+4/CD^+8及NK细胞水平变化、治疗前后QOL评分和KPS评分。结果治疗组治疗后总有效率为78.26%(36/46),对照组治疗后总有效率为93.48%(43/46),治疗组治疗总有效率高于对照组(P<0.05);治疗组治疗后阴道流血、心烦易怒、胸胁胀痛、口苦咽干和全身窜痛等中医症候积分低于对照组(P<0.05);治疗组治疗后T淋巴细胞亚群CD^+3、CD^+4、CD^+4/CD^+8及NK细胞水平高于对照组,CD^+8水平低于对照组(P<0.05);治疗组治疗后QOL评分和KPS评分高于对照组(P<0.05)。结论疏肝化郁解毒汤对子宫颈癌术后化疗患者的治疗效果确切,可有效的改善患者的临床症状,提高术后机体免疫力,调节患者血清Th1/Th2细胞相关因子,改善健康状况,提高治疗疗效,值得临床推广应用。
Objective To evaluate the therapeutic effect of Shugan Huayu Jiedu Decoction on cervical cancer patients undergoing chemotherapy after operation and its effect on serum Th1/Th2.Methods Ninety-two patients with cervical cancer admitted to our hospital from March 2017 to February 2019 were selected and divided into treatment group and control group according to random control method,46 cases in each group.The control group was treated with docetaxel plus oxaliplatin,while the treatment group was treated with Shugan Huayu Jiedu Decoction.Four weeks was a cycle and three cycles were carried out.The changes of TCM symptom score,therapeutic effect,serum Th1/Th2 related factors before and after treatment,levels of T lymphocyte subsets CD^+3,CD^+4,CD^+8,CD^+4/CD^+8 and NK cell before and after treatment,QOL score and KPS score before and after treatment were compared between the two groups.Result The total effective rate of treatment group was 93.48%(43/46),that of control group was 78.26%(36/46).The total effective rate of the treatment group was higher than that of the control group(P<0.05).The levels of CD^+8 and NK cells in the treatment group were higher than those in the control group,and the level of CD^+8 were lower than that in the control group(P<0.05).The QOL score and KPS score in the treatment group were higher than those in the control group(P<0.05).Conclusion Shugan Huayu Jiedu Decoction is effective in the treatment of patients with cervical cancer after chemotherapy.It can effectively improve the clinical symptoms and the immunity,regulate the serum Th1/Th2 cell-related factors,improve the health status andthe therapeutic effect.It is worthy of clinical application.
作者
郜智慧
王倩青
GAO ZhiHui;WANG Qianqing(Department of Gynecology Oncology,Xinxiang Central Hospital,Xinxiang 453000,Henan,China)
出处
《中华中医药学刊》
CAS
北大核心
2020年第6期240-243,共4页
Chinese Archives of Traditional Chinese Medicine
基金
河南省重点科技攻关计划(102102310101)。
