摘要
目的探讨急性冠状动脉综合征(ACS)患者经皮冠状动脉介入治疗(PCI)术后血清溶血磷脂酰肌醇(LPI)水平变化及意义。方法选取2015年5月至2018年5月汉中市三二〇一医院收治的203例ACS患者作为研究对象。根据血清LPI值评估ACS患者预后的最佳截断点(1.04μmol/L),将患者分为高LPI组(n=46)和低LPI组(n=157)。检测患者血清LPI水平,并分析其与预后的关系。结果血清LPI评估ACS患者预后的受试者工作特征曲线下面积(AUC)为0.851,灵敏度、特异度分别为69.44%、88.02%。高LPI组、低LPI组患者间血肌酐、肌钙蛋白I(TnI)、病变血管数、美国纽约心脏病协会(NYHA)心功能分级、糖化血红蛋白(HbA1c)、尿素氮(BUN)、左心室射血分数(LVEF)、LPI差异均有统计学意义(P<0.05)。高LPI组主要心血管不良事件(MACE)发生率显著高于低LPI组,平均生存时间显著低于低LPI组,差异均有统计学意义(P<0.001)。Cox单因素和多因素回归分析显示,疾病分型、慢性阻塞性肺疾病、TnI、病变血管数、LPI与ACS患者预后密切相关。结论血清LPI与ACS患者预后密切相关。LPI水平检测有助于评估患者预后。
Objective To investigate the changes of serum lysophosphatidylinositol(LPI)levels in patients with acute coronary syndrome(ACS)after percutaneous coronary intervention(PCI),and to discuss its clinical significance.Methods A total of 203 patients with ACS,who were admitted to Hanzhong Municipal No.3201 Hospitalof China during the period from May 2015 to May 2018,were enrolled in this study.According to the optimal cut-off point of serum LPI(1.04μmol/L),the patients were divided into high-LPI group(n=46)and low-LPI group(n=157).The patients’serum LPI levels were measured and its relationship with the prognosis was analyzed.Results The AUC,sensitivity and specificity of serum LPI in evaluating the prognosis of ACS patients were 0.851,69.44%and 88.02%,respectively.There were significant differences in serum creatinine,troponin I(TnI),number of diseased vessels,NYHA cardiac functional grading,hemoglobin A1C(HbA1c),urea nitrogen(BUN),left ventricular ejection fraction(LVEF)and LPI levels between the high-LPI group and the low-LPI group(P<0.05).The incidence of MACE in the high-LPI group was obviously higher than that in the low-LPI group,while the mean survival time in the high-LPI group was remarkably lower than that in the low-LPI group,the differenceswere statistically significant(P<0.001).Cox univariate analysis and multivariate analysis showed that the disease classification,chronic obstructive pulmonary disease,TnI,lesion branches,and LPI level were closely related to the prognosis of patients with ACS.Conclusion Serum LPI level is closely related to the prognosis of patients with ACS.The detection of LPI level is very helpful in evaluating the prognosis of patients.
作者
唐荣
梁建军
TANG Rong;LIANG Jianjun(Department of Emergency,Hanzhong Municipal No.3201 Hospital,Hanzhong,Shaanxi Province 723000,China)
出处
《介入放射学杂志》
CSCD
北大核心
2020年第6期555-559,共5页
Journal of Interventional Radiology
