摘要
目的比较利培酮单用或联合改良电抽搐治疗(MECT)对精神分裂症患者血清C反应蛋白(CRP)的影响。方法收集只接受利培酮治疗(服药组)和联合接受改良电休克治疗(MECT组)的患者及正常人(正常组)各30例,观察4周,采用阳性和阴性症状量表(PANSS)对患者治疗前后精神症状进行评定,同时检测患者治疗前后和正常人的血清CRP浓度。结果治疗前两组患者血清CRP浓度均高于正常组(P<0.01);治疗后两组血清CRP浓度均低于治疗前(P<0.01),但是仍然高于正常组(P<0.01)。两组患者中治疗有效者血清CRP浓度显著低于治疗前(P<0.01),治疗无效者治疗前后血清CRP浓度差异均无统计学意义(P>0.05)。结论MECT和抗精神病药物治疗均可能通过降低炎症水平(降低CRP)而起到抗精神病的作用。
Objective To explore the effect of modified electroconvulsive therapy(MECT)and risperidone on serum C-reactive protein(CRP)in schizophrenia patients.Method Collect only accept risperidone treatment in schizophrenia(Medication group),and select the age-and sex-matched 30 schizophrenia(MECT group)who were treated with MECT and risperidone.The serum CRP levels were measured by enzyme-linked immunosorbent assay in schizophrenia patients before and after treatment and 30 normal controls(Normal group).A positive and negative syndrome scale(PANSS)questionnaire has been used to recognize the severity of the disease and to assess the response to treatment.Results Before treatment,the serum CRP levels in two patient groups were significantly higher than the levels in normal group(P<0.01).After treatment,the serum CRP levels are significantly decrease as compare to before treatment in patient groups(P<0.01),but still higher than normal group(P<0.01).CRP levels in patient groups of responders after treatment were lower than before treatment(P<0.01).No statistical significance in non-responders(P>0.05).Conclusion MECT and antipsychotic medications may play a role in schizophrenia through decreasing the serum level of CRP.
作者
曹月梅
成红霞
陈宽玉
肖文焕
CAO Yuemei;CHENG Hongxia;CHEN Kuanyu(Wutaishan hospital of Yangzhou,Yangzhou 225003,China)
出处
《国际精神病学杂志》
2020年第3期472-474,488,共4页
Journal Of International Psychiatry
