摘要
目的探讨氟西汀与阿米替林对酒精依赖戒断后情感障碍的临床疗效比较。方法选取本院2018年12月~2019年12月接受治疗的酒精依赖戒断后情感障碍患者94例作为研究对象,按随机数字表法将研究对象随机分为观察组和对照组,每组各52例。观察组接受氟西汀治疗,对照组接受阿米替林治疗。观察比较两组患者治疗前后躁狂量表(BRMS)评分、焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分,血清神经肽Y(NPY)、5-羟色胺(5-HT)及不良反应。结果(1)治疗后,两组患者的BRMS、SAS、SDS评分较前明显降低,且观察组评分明显低于对照组(P<0.05);(2)治疗后,两组患者的血清NPY和5-HT水平较前明显升高,且观察组水平明显高于对照组(P<0.05);(3)两组患者药物不良反应差异无统计学意义(χ2=1.760,P>0.05)。结论在酒精依赖戒断后情感障碍的治疗中,氟西汀疗效优于阿米替林,其机制可能与提高血清NPY、5-HT的水平相关,值得临床推广应用。
Objective To study the effect of fluoxetine and amitriptyline on mood disorders after alcohol dependence withdrawal.Methods A total of 80 patientswith mood disorders after alcohol dependence withdrawal in our hospital from December 2018 to December 2019 were collected and randomly divided into two groups:the control group(52 cases)were treated with amitriptyline,observation group(52 cases)were treated with fluoxetine.Manic scale(BRMS)score,self-rating anxiety scale(SAS),self-rating depression scale(SDS),neuropeptide Y(NPY),serotonin(5-HT before and after treatment,and adverse reactions between the two groups were compared.Results(1)After treatment,the scores of BRMS,SAS and SDS in the two groups were significantly lower than before,and the scores in the observation group were significantly lower than those in the control group(P<0.05).(2)After treatment,the serum levels of NPY and 5-HT in the two groups were significantly higher than before,and the levels in the observation group was significantly higher than that in the control group(P<0.05).(3)There was no significantly difference in adverse drug reactions between the two groups(P>0.05).Conclusion In the treatment of mood disorders after alcohol dependence withdrawal,fluoxetine is superior to amitriptyline in the improvement of mania,anxiety and depression,and its mechanism may be related to the improvement of serum NPY and 5-ht,which is worthy of clinical application.
作者
袁利艳
杨颜滋
李江琳
YUAN Liyan;YANG Yanzi;LI Jianglin(First Affiliated Hospital of Henan University,Kaifeng 475000,China)
出处
《国际精神病学杂志》
2020年第3期507-509,共3页
Journal Of International Psychiatry
基金
开封市科技发展项目(编号:1903041)。
关键词
氟西汀
阿米替林
酒精依赖
情感障碍
Fluoxetine
Amitriptyline
Alcohol dependence
Mood disorder
