摘要
目的探讨奥美拉唑联合去甲肾上腺素治疗上消化道出血疗效。方法选取我院(2016年1月至2018年1月)收治的100例上消化道出血患者,根据不同治疗方法分为两组,对照组(n=50)接受奥美拉唑治疗,观察组(n=50)再对照组基础上接受甲肾上腺素治疗,对比两组患者临床观察指标和临床疗效以及不良反应发生情况。结果观察组止血时间(1.54±0.28)d明显快于对照组(2.24±0.62)d,输血量(247.57±29.72)mL治疗费用(3541.39±340.45)元明显少于对照组(357.29±31.50)m L、(5237.98±542.26)元,输血时间(4.38±1.65)h、住院时间(5.76±2.03)d明显短于对照组(7.36±1.21)h、(8.07±2.52)d,差异具有统计学意义(t=7.2759、17.9147、10.2984、5.0477、18.7368,P<0.05);胃癌、急性糜烂出血性胃炎、食管胃底静脉曲张破裂、消化性溃疡总有效率100.00%、92.86%、60.00%、90.91%明显高于对照组80.00%、80.00%、25.00%、66.67%,差异具有统计学意义(χ~2=22.2222、7.0503、25.0639、17.5802,P<0.05)。结论上消化道出血采用奥美拉唑联合去甲肾上腺素治疗效果显著,值得临床推广。
Objective To investigate the efficacy of omeprazole combined with norepinephrine in the treatment of upper gastrointestinal bleeding.Methods To choose the hospital(from January 2016 to January 2018)treated 100 patients with upper gastrointestinal bleeding,according to the different treatment methods are divided into two groups,control group(n=50)treated with omeprazole,observation group(n=50)and the control group treated with norepinephrine,on the basis of compared two groups of patients with clinical observation indexes and clinical curative effect and adverse reactions occur.Results Hemostasis time(1.54±0.28)d in the observation group was significantly faster than that in the control group(2.24±0.62)d,transfusion volume(247.57±29.72)mL,treatment cost(3541.39±340.45)yuan,Significantly less than the control group(357.29±31.50)mL,(5237.98±542.26)yuan,transfusion time(4.38±1.65)h,hospitalization time(5.76±2.03)d were significantly shorter than that in the control group(7.36±1.21)h,8.07±2.52)d.The differences were statistically significant(t=7.2759,17.9147,10.2984,5.0477.18.7368.P<0.05).The total effective rate of gastric cancer,acute erosive hemorrhagic gastritis,esophageal and gastric varices rupture,peptic ulcer was100.00%,92.86%,60.00%,90.91%,significantly higher than that of the control group(80.00%,80.00%,25.00%,66.67%),and the difference was statistically significant(χ~2=22.2222,7.0503,25.0639,17.5802,P<0.05).Conclusion Omeprazole combined with norepinephrine for treatment of upper gastrointestinal hemorrhage is effective and worthy of clinical promotion.
作者
毛秀娟
MAO Xiu-juan(Zhuanghe Central Hospital,Dalian 116400,China)
出处
《中国医药指南》
2020年第20期113-114,共2页
Guide of China Medicine
关键词
上消化道出血
奥美拉唑
去甲肾上腺素
Upper gastrointestinal bleeding
Omeprazole
Norepinephrine
