探讨阿司匹林联合地屈孕酮治疗习惯性流产的临床疗效被引量：8

Discussion on clinical effect of aspirin combined with dydrogesterone on habitual abortion

下载PDF

导出

摘要目的探讨阿司匹林联合地屈孕酮治疗习惯性流产的效果。方法 108例习惯性流产患者,随机分为实验组与对照组,各54例。对照组应用黄体酮联合人绒毛膜促性腺激素治疗,实验组给予阿司匹林联合地屈孕酮治疗。观察比较两组治疗效果、临床症状持续时间、临床指标、安全性。结果实验组总有效率98.15%高于对照组的77.78%,差异有统计学意义(P<0.05)。实验组腹痛、下腹坠胀、腰痛和阴道流血持续时间分别为(5.59±1.27)、(4.11±0.76)、(6.06±1.13)、(5.42±1.67)d,短于对照组的(9.13±2.06)、(6.97±0.85)、(9.78±1.49)、(8.61±1.95)d,差异有统计学意义(P<0.05)。治疗后,实验组凝血酶原时间(PT)(13.52±1.75)s长于对照组的(11.36±0.96)s,白细胞介素-4(IL-4)(219.86±23.57)ng/L高于对照组的(190.53±16.73)ng/L, D-二聚体(542.14±21.52)μg/L、血清干扰素-γ(IFN-γ)(0.71±0.13)ng/L低于对照组的(641.95±31.29)μg/L、(0.89±0.18)ng/L,差异均有统计学意义(P<0.05)。实验组不良反应发生率7.41%明显低于对照组的22.22%,差异有统计学意义(P<0.05)。结论针对习惯性流产患者应用阿司匹林联合地屈孕酮治疗效果显著,能够缩短症状持续时间,改善凝血和免疫功能水平,安全性高,值得推广应用。 Objective To discuss the effect of aspirin combined with dydrogesterone on habitual abortion. Methods A total of 108 habitual abortion patients were randomly divided into experimental group and control group, with 54 cases in each group. The control group was treated by progesterone combined with human chorionic gonadotropin, and the experimental group was treated by aspirin combined with dydrogesterone. The therapeutic effect, duration of clinical symptoms, clinical indicators and safety of the two groups were observed and compared. Results The total effective rate 98.15% of the experimental group was higher than that of the control group 77.78%, and the difference was statistically significant(P<0.05). The duration of abdominal pain, lower abdominal distension, low back pain and vaginal bleeding of the experimental group were(5.59±1.27),(4.11±0.76),(6.06±1.13) and(5.42±1.67) d respectively, which were shorter than those of the control group(9.13±2.06),(6.97±0.85),(9.78±1.49) and(8.61±1.95) d, and the difference was statistically significant(P<0.05). After treatment, prothrombin time(PT)(13.52±1.75) s of the experimental group was longer than that of the control group(11.36±0.96) s, interleukin-4(IL-4)(219.86±23.57) ng/L was higher than that of the control group(190.53±16.73) ng/L, and D-dimer(542.14±21.52) μg/L, serum interferon-γ(IFN-γ)(0.71±0.13) ng/L were lower than those of the control group(641.95±31.29) μg/L,(0.89±0.18) ng/L, and the difference was statistically significant(P<0.05). The incidence of adverse reactions 7.41% of the experimental group was obviously lower than that of the control group 22.22%, and the difference was statistically significant(P<0.05). Conclusion Aspirin combined with dydrogesterone shows remarkable effect on habitual abortion, which can shorten duration of symptoms, improve blood coagulation and immune function with high safety. It is worth popularizing and applying.