摘要
目的评价2014—2018年陕西省榆林市榆阳区成人大骨节病药物治疗效果,为改善大骨节病病人临床症状和生命质量提供参考。方法在榆阳区10个大骨节病病区乡(镇)筛选临床症状和体征分度标准Ⅰ度以上、年龄65岁以下的大骨节病病人进行药物治疗,治疗药物为口服盐酸氨基葡萄糖胶囊,合用止痛药塞来昔布胶囊,另加辅助药21金维他,以上药物均严格按照说明书剂量服用12 w;临床疗效观察参照《大骨节病治疗效果判定》标准,采用卡方检验和Logistic回归统计分析。结果 2014—2018年榆阳区共治疗成人大骨节病病人2 103例,其中男性占57.11%,年龄中位数为57岁;药物治疗显效率37.57%、有效率56.92%、无效率5.52%,病人Ⅰ度1 033例、Ⅱ度990例、Ⅲ度80例,不同临床类型成人大骨节病病人药物治疗效果差异有统计意义(χ^2=31.829,P<0.001),其中Ⅰ度病人显效率最高(42.30%)、Ⅱ度病人有效率最高(63.23%)、Ⅲ度病人无效率最高(7.50%);多元Logistic回归分析表明,与无效病人相比,男性、年龄57岁以下与药物治疗显效呈正相关,但显效与临床分型不相关;男性与药物治疗有效不相关,年龄57岁以下与药物治疗有效呈负相关,临床Ⅱ度与药物治疗有效呈正相关。结论成人大骨节病药物治疗效果较好;应关注病人性别、年龄和临床分度对药物治疗效果的影响。
Objective To evaluate the effect of drug therapy of adult patients with Kaschin-Beck disease(KBD) at Yuyang district of Yulin city in Shaanxi province from 2014 to 2018, and provide a reference for improving clinical symptoms and quality of life of the patients. Methods The KBD patients under the age of 65 years and with clinical symptoms and signs above grade Ⅰ were selected for drug therapy at 10 townships of Yuyang district with KBD epidemic. Glucosamine hydrochloride caps was selected as the treatment drug, combined with the analgesic of Celecoxib caps and pill of 21 SuperVita as the adjuvant drug. All the drugs were strictly taken according to the instructions for 12 weeks. The clinical efficacy was observed based on the Judging Treatment Effect on Kaschin-Beck Disease. Data were statistically analyzed with Chisquare test and Logistic regression. Results There were 2 103 adult patients with KBD treated from 2014 to 2018, with57.11% of male patients, and median of age was 57 years. The rate was 37.57% of the markedly effective, 56.92% of the effective, and 5.52% of the invalid. Totally the patients were 1 033 of grade Ⅰ, 990 of grade Ⅱ, and 80 of grade Ⅲ. The effects of drug therapy had statistical difference(χ^2=31.829, P<0.001) among the patients of different grade. out of them, the rate was the highest of the markedly effective(42.30%) in the patients of grade Ⅰ, of the effective(63.23%) in the patients of grade Ⅱ,and of the invalid(7.50%) in patients of grade Ⅲ. Compared with the inefficient patients by multiple Logistic regression analysis, the marked effect of drugs positively correlated with the factors of the male, patients under 57 years old, but didn′t correlate with clinical grades. The efficiency of drug therapy positively correlated with the factors of the male and clinical grade Ⅱ, and negatively correlated with the factor of age under 57 years. Conclusions The efficacy of drug therapy is good for adult patients with KBD. Attention should be paid to the influences of gender, age and clinical grade of patient on the drug therapy.
作者
张伟
白小琴
刘小燕
ZHANG Wei;BAI Xiao-qin;LIU Xiao-yan(Yulin Municipal Institute for Endemic Disease Control and Research,Yulin,Shaanxi 719000,China)
出处
《疾病预防控制通报》
2020年第3期48-51,共4页
Bulletin of Disease Control & Prevention(China)
关键词
大骨节病
药物治疗
效果分析
Kaschin-Beck disease(KBD)
Drug therapy
Effect analysis
