摘要
目的:探讨桂枝茯苓汤联合炔诺酮片治疗子宫内膜异位症疗效及对血清环氧化酶(COX-2)、巨噬细胞移动抑制因子(MIF)水平影响。方法:选取2017年1月-2018年2月本院收治的132例子宫内膜异位症患者,随机分为3组,西药组口服炔诺酮片治疗,中药口服桂枝茯苓汤剂治疗,中西药组采用炔诺酮片联合桂枝茯苓汤治疗,对比3组临床效果、不良反应发生、视觉模拟法(VAS)疼痛评分、生活质量及血清COX-2、MIF水平。结果:中西药组总有效率(95.5%)高于西药组(84.1%)和中药组(86.4%),VAS评分痛经(1.12±0.50分)、慢性盆腔痛(1.31±0.37分)、性交痛(1.12±0.21分)均低于另外两组,血清COX-2(24.54±4.32 ng/ml)、MIF(10.98±3.23 ng/ml)水平低于另外两组,生活质量评分(94.2±5.4分)最高(均P<0.05),不良反应(4.6%)与另外两组无差异(P>0. 05)。结论:子宫内膜异位症患者采用桂枝茯苓汤联合炔诺酮片治疗,能更好改善患者临床症状,减少痛经及性生活疼痛感,快速降低COX-2及MIF水平,且不增加不良反应。
Objective:To investigate the effect of Guizhi fuling decoction combined with norethisterone tablets for treating women with endometriosis, and to study it influence on their serum COX-2 and macrophage movement inhibition factor(MIF) levels. Methods: 132 women with endometriosis were randomly divided into three groups from January 2017 to February 2018. The women in group A were treated with norethindrone tablet, the women in group B were treated with Guizhi fuling decoction oral, and the women in group C were treated with Guizhi fuling decoction oral combined with norethindrone tablet. The treatment efficacy, adverse effects, VAS score, quality of life, and serum COX-2 and MIF levels of women were compared among the three groups. Results: The total effective rate of women in group C was 95.5%, which was significant higher than that(84.1%) of women in group A and that(86.4%) of women in group B. The pain VAS score, chronic pelvic pain score, intercourse pain score, and the serum COX-2 and MIF levels of women in group C were 1.12±0.50 points, 1.31±0.37 points, 1.12±0.21 points, and 24.54 ± 4.32 ng/ml and 10.98 ± 3.23 ng/ml, which were significant lower than those of women in group A and B. The quality of life score of women in group C was 94.2±5.4 points, which was the highest in the three groups(all P<0.05). The adverse reactions of women in group C was 4.6%, which had no difference from that of women in other two groups(P>0.05). Conclusion: Guizhi fuling decoction combined with norethisterone tablets for treating women with endometriosis can improve their clinical symptoms of the patients quickly, reduce their pain of dysmenorrhea and sexual life, and improve their quality of life, which can significantly reduce their serum COX-2 and MIF levels without increasing the adverse reaction.
作者
胡小欣
汤健聪
陈冬梅
HU Xiaoxin;TANG Jiancong;CHEN Dongmei(Sun Yat-sen Memorial Hospital,Zhongshan University,Guangdong Province,510120;Xiaolan People’s Hhospital of Zhongshan)
出处
《中国计划生育学杂志》
2020年第7期1022-1025,共4页
Chinese Journal of Family Planning
