摘要
目的检测青年急性脑梗死(young acute cerebral infarction,YACI)患者血清降钙素原(procalcitonin,PCT)水平,探讨其与YACI患者脑梗死体积的关系。方法根据脑梗死体积将首次入院的YACI患者(观察组)分为大脑梗死组(18 cases)、中梗死组(31 cases)和小梗死组(37 cases),依据美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分判定患者临床症状的严重程度。另外选取同期行头部DWI检查结果正常的72例健康体检青年人作为对照组,采用ELISA法测定血清降钙素原水平,分析血清降钙素原与NIHSS评分及脑梗死体积的关系。结果观察组患者血清PCT水平明显高于对照组,NIHSS评分重症组患者血清PCT水平明显高于轻症组,大梗死组患者PCT水平高于中梗死组及小梗死组,中梗死组患者PCT水平高于小梗死组。观察组患者PCT水平与NIHSS评分及梗死体积均呈正相关。结论YACI患者血清PCT水平可能与脑梗死后脑动脉炎症反应有关,与NIHSS评分及脑梗死体积均呈正相关,在一定程度上可以预测YACI患者的病情严重程度,值得临床推广应用。
Objective To detect the serum procalcitonin(PCT)levels in young patients with acute cerebral infarction(YACI)and study its relationship with the infarct volume of YACI patients.Methods According to the volume of cerebral infarction,YACI patients(observation group)who were admitted for the first time were divided into large cerebral infarction group(18 patients),middle cerebral infarction group(31 patients),and small cerebral infarction group(37 patients).The severity of clinical symptoms was determined using the National Institute of Health Stroke Scale score.In addition,72 healthy young people with brain diffusion weighted imaging examinations within the normal range during the same period were selected as the control group.Serum procalcitonin levels were measured by enzyme-linked immune sorbent assay(ELISA).The relationship among serum procalcitonin,young acute cerebral infarction volume and NIHSS score was analyzed.Results Serum PCT levels in observation group were significantly higher than those in control group,NIHSS of severe group were significantly higher than those of mild group.The levels of PCT in large infarction group was higher than that in middle infarction group and small infarction group,while the levels of PCT in middle infarction group was higher than that in small infarction group.PCT levels were positively correlated with NIHSS score and infarct volume in the observation group.Conclusion The levels of serum PCT in YACI patients may be related to the inflammatory reaction of the cerebral artery after cerebral infarction and positively related to the volume of cerebral infarction and NIHSS score.PCT concentration can predict the disease severity of YACI patients,and is of clinical application value.
作者
鱼海
陈颖聪
温慧军
YU Hai;CHEN Yingcong;WEN Huijun(Department of Neurology,Baoji Municipal Central Hospital,Baoji,Shanxi 721008,China)
出处
《中风与神经疾病杂志》
CAS
2020年第6期547-550,共4页
Journal of Apoplexy and Nervous Diseases
关键词
降钙素原
急性脑梗死
青年
梗死体积
神经功能缺损
Procalcitonin
Acute cerebral infarction
Young
Infarct volume
Neurological deficit
