摘要
目的探讨局限期小细胞肺癌常规分割放疗与加速超分割放疗的临床治疗效果差异。方法选择接受治疗的小细胞肺癌患者60例,按照入院日期单日、双日的区别分为对照组30例和观察组30例。对照组在常规化疗基础上给予常规分割放疗,观察组则在常规化疗基础上给予加速超分割放疗,对比治疗效果。结果观察组的治疗效果、治疗有效率和疾病控制率均优于对照组(Z=2.579,χ^2=5.079、4.630,P<0.05)。两组在治疗期间的各类不良反应发生率差异无统计学意义(χ^2=1.022、0.884、0.077、0.000、0.000、0.417、1.832、0.693,P>0.05)。对照组的总生存时间中位数为23.012个月,观察组的总生存时间中位数为26.976个月,差异有统计学意义(χ^2=5.741,P<0.05)。结论采用加速超分割放疗的方法治疗局限期小细胞肺癌患者,可以提升治疗效果,延长生存时间,安全性良好。
Objective To investigate the difference in clinical treatment between conventional segmented radiotherapy and hyperfractionated accelerated radiotherapy for limited-stage small cell lung cancer.Methods Sixty patients with small cell lung cancer between January 2012 and March 2016 were selected.According to the odd-or even-number day of admission,30 patients in the control group and 30 patients in the observation group were assigned.The patients in control group received conventional fractionated radiotherapy on the basis of conventional chemotherapy;and in the observation group received accelerated hyperfractionated radiotherapy based on conventional chemotherapy.Results The therapeutic effect,treatment efficiency and disease control rate of the observation group were significantly better than those of the control group(Z=2.579,χ^2=5.079,χ^2=4.630,respectively,P<0.05).There were no significant differences in the data of various adverse reactions between the two groups during the treatment period(P>0.05).The median overall survival of the control group was 23.012 months(95%CI:12.269-31.751 months),and the median overall survival of the observation group was 26.976 months(95%CI:20.257-28.351 months);with significant difference between the 2 groups(χ^2=5.741,P<0.05).Conclusion Treatment of patients with limited-stage small cell lung cancer by accelerated hyperfractionated radiotherapy can improve treatment and prolong survival,with good safety.
作者
宋慧胜
李志英
王馨
冯正富
潘辉林
周政涛
SONG Hui-sheng;LI Zhi-ying;WANG Xin;FENG Zheng-fu;PAN Hui-lin;ZHOU Zheng-tao(Department of oncology,the Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People's Hospital,Guangdong,China)
出处
《广东医学》
CAS
2020年第12期1259-1262,共4页
Guangdong Medical Journal
关键词
小细胞肺癌
放疗
生存时间
不良反应
Small cell lung cancer
Radiotherapy
Survival time
Adverse reactions
