摘要
目的探讨心房颤动患者血清尿酸水平与心功能的相关性。方法选取2012年5月~2017年12月于我院心内科就诊的心房颤动患者184例,分别记录患者性别,年龄,血清尿酸水平,心功能分级,心脏彩超指标:左房内径(LAD)、左室收缩末期内径(LVSDD)、左室舒张末期内径(LVEDD)、左室后壁厚度(LVPW)、室间隔厚度(IVS)、射血分数(EF)。依据患者血清尿酸水平是否增高,将患者分为房颤伴血尿酸增高组(A组)与房颤不伴血尿酸增高组(B组),其中A组68例,B组116例。结果房颤伴血尿酸增高组与房颤不伴血尿酸增高组相比较,心功能较差(P<0.05),心脏彩超指标LAD显著增大(P<0.05),LVEDD、LVSDD、IVS、LVPW、EF差异无统计学意义。相关性分析示血清尿酸水平与LAD、LVEDD、LVSDD呈正相关(P<0.05),与IVS、LVPW、EF之间无相关性。结论房颤伴血尿酸增高使心功能明显变差,且会导致患者左房内径增大,并随血尿酸水平的增加而增大。
Objective To explore the correlation between serum uric acid level and cardiac function in patients with atrial fibrillation.Methods A total of 184 patients with atrial fibrillation who were treated in our hospital’s department of cardiology from May 2012 to December 2017 were selected,and their gender,age,serum uric acid levels,cardiac function grade,and cardiac color ultrasound indicators[left atrial diameter(LAD),left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD),left ventricular posterior wall thickness(LVPW),interventricular septum thickness(IVS),and ejection fraction(EF)]were documented.According to whether the serum uric acid level of the patients was increased,the patients were divided into the atrial fibrillation with elevated blood uric acid group(n=68,group A)and the atrial fibrillation without elevated blood uric acid group(n=116,group B).Results The cardiac function in group A was worse than that in group B(P<0.05);the cardiac color Doppler ultrasound index LAD increased significantly(P<0.05);There was no significant difference in LVEDD,LVESD,IVS,LVPW and EF between the two groups.Correlation analysis showed that serum uric acid levels were positively correlated with LAD,LVEDD,and LVESD(P<0.05),and were not correlated with IVS,LVPW,and EF.Conclusion Atrial fibrillation with elevated blood uric acid significantly worsens cardiac function,and can lead to an increase in the LAD,which increases with the elevation of blood uric acid level.
作者
张凤
赵亮
ZHANG Feng;ZHAO Liang(Department of Cardiology,Lingcheng People’s Hospital,Shandong,Dezhou 253500,China)
出处
《中国医药科学》
2020年第13期220-222,229,共4页
China Medicine And Pharmacy
关键词
心房颤动
血尿酸
左房内径
心功能
Atrial fibrillation
Uric acid
Left atrial diameter
Cardiac function
