摘要
目的通过系统分析骨肉瘤肺转移化疗情况的研究现状,了解国内化疗情况的策略,明确存在的问题,为今后的研究方向提供参考。方法检索中国学术期刊全文数据库(CNKI)2000-01-01/2019-06-30刊载的符合条件的中文文献,利用数据库自带的分析功能及Excel建立评价数据库对检索结果等内容进行统计及可视化分析。结果截至2019-06-30,共筛选了195篇相关文献,2004年开始发文量逐渐增长,2014年发文量最高,为30篇。2015年文献量呈现下降趋势。关键词出现频次依次为:转移102次、骨肉瘤病63次、Osteosarcoma(骨肉瘤)67次、骨肉瘤细胞57次、骨肉瘤55次、新辅助化疗39次。研究热点主要集中在新辅助化疗、生存分析、中位生存时间等具体疗效方面,细胞凋亡、免疫组织化等基础研究方面。研究机构主要是高等院校及附属医疗机构,依次为上海交通大学第六附属医院(9.7%),北京大学人民医院(6.2%)、浙江大学(5.3%)等。文献来源排名靠前的集中于《肿瘤》、《临床肿瘤学杂志》等核心期刊。结论骨肉瘤肺转移的化疗相关研究越来越受到医疗机构的重视,总体质量较高,后期应增加化疗药物在疗效方面的研究深度及更佳化疗方案的探索。
Objective To systematically analyze the current status of osteosarcoma lung metastasis chemotherapy in order to understand the domestic chemotherapy situation,clear the existing problems and to provide references for future research directions. Methods Chinese documents about osteosarcoma lung metastasis chemotherapy published in the Chinese Academic Journal Full-text Database(CNKI) 2000-01-01/2019-06-30 were searched. An evaluation database was established by using the analysis function of the CNKI database and Excel for statistical and visual analysis.Results By the end of 2019-06-30,a total of 195 related literatures were screened. The number of publications began to increase gradually since 2004. The number of publications was the most in2014,with 30 articles published. In 2015,the amount of literature showed a downward trend. The frequency of occurrence of the keywords was as follows: metastasis 102 times, osteosarcoma 63 times, osteosarcoma(osteosarcoma) 67 times, osteosarcoma cells 57 times, osteosarcoma 55 times and neoadjuvant chemotherapy 39 times. Research hotspots mainly focus on specific therapeutic effects, such as neoadjuvant chemotherapy, survival analysis, median survival time, and basic research, such as apoptosis and immune organization. The research institutions are mainly institutions of higher learning and affiliated medical institutions, such as the Sixth Hospital of Shanghai Jiao tong University(9.7%), Peking University People’s Hospital(6.2%), and Zhejiang University(5.3%). The main sources of literature are core journals such as Tumor and Clinical Oncology. Conclusion Chemotherapy-related studies of osteosarcoma lung metastasis have received increasing attention from medical institutions,and the overall quality is high. The depth of research on the efficacy of chemotherapy drugs and the exploration of better chemotherapy regimens should be strengthened.
作者
王晓芹
王琼芳
张容
孙婕
解仕芳
WANG Xiaoqin;WANG Qiongfang;ZHANG Rong;SUN Jie;XIE Shifang(Sichuan Cancer Hospital,Chengdu 610041,Sichuan Province,China;Sichuan Provincial People's Hospital,Chengdu 610072,Sichuan Province,China;First People's Hospital of Chengdu,Chengdu 610016,Sichuan Province,China;Butuo County Center for Disease Control and Prevention,Liangshan Yi Autonomous Prefecture 616350,Sichuan Province,China)
出处
《预防医学情报杂志》
CAS
2020年第7期940-945,共6页
Journal of Preventive Medicine Information
基金
四川省干部保健科研课题(项目编号:川干研2019-228)。
