摘要
目的探讨罗红霉素联合N-乙酰半胱氨酸对慢性阻塞性肺疾病合并肺间质纤维化(COPD-PIF)的疗效及对肺功能的影响。方法选取接受治疗的COPD-PIF患者96例为研究对象,按照随机数字表法分为2组。对照组48例采用罗红霉素治疗,试验组48例在对照组基础上加用N-乙酰半胱氨酸治疗,均连续治疗3个月。比较2组治疗有效率、治疗前后肺功能指标和血清炎性指标变化、不良反应发生情况和生存质量评分。结果96例患者中共92例完成本研究,其中试验组47例,对照组45例。试验组患者治疗有效率为93.62%,与对照组的84.44%比较差异无统计学意义(P>0.05)。治疗后,试验组肺活量(VC)、第一秒用力呼气量(FEV 1)、肺一氧化碳弥散量(DISO)占预估值的百分比显著高于对照组(P<0.05)。治疗后,试验组白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平均显著低于对照组(P<0.05)。2组不良反应及治疗后生存质量评分比较,差异无统计学意义(P>0.05)。结论罗红霉素联合N-乙酰半胱氨酸对COPD-PIF患者的疗效显著,可有效改善患者肺功能指标和血清炎性因子指标,且不会增加不良反应。
Objective To explore effect of roxithromycin combined with N-acetylcysteine in treatment of chronic obstructive pulmonary disease patients complicating with pulmonary interstitial fibrosis(COPD-PIF)and its influence on pulmonary function.Methods A total of 96 COPD-PIF patients with treatment were enrolled,and were divided into two groups according to random number table method,with 48 cases in each group.The control group was treated with roxithromycin,while experimental group was additionally treated with N-acetylcysteine on basis of control group.All of them were continuously treated for 3 months.The efficacy rate of treatment,changes of lung function indexes and serum inflammatory indexes before and after treatment,occurrence of adverse reactions and quality of life scores were compared between the two groups.Results Out of the 96 patients,there were 92 cases accomplished the experiment,including 47 cases in experimental group and 45 cases in control group.There was no significant difference in efficacy rate of treatment between experimental group and control group(93.62%vs.84.44%,P>0.05).After treatment,ratios of vital capacity(VC),forced expiratory volume in 1 second(FEV 1),and carbon monoxide diffusion capacity(DISO)to predicted value in experimental group were significantly higher than those in control group(P<0.05).After treatment,levels of interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)in experimental group were lower than those in control group(P<0.05).There were no significant differences in incidence of adverse reactions and quality of life scores after treatment between the two groups(P>0.05).Conclusion Roxithromycin combined with N-acetylcysteine has significant efficacy in treating COPD-PIF patients,which can effectively improve lung function indexes and serum inflammatory factors,and has no increase in adverse reactions.
作者
陆涛
左俊丽
LU Tao;ZUO Junli(Department of Pharmacy,Shangnan County Hospital,Shangluo,Shaanxi,726300;Department of Respiratory and Critical Care Medicine,Xi'an International Medical Center Hospital,Xi'an,Shaanxi,710100)
出处
《实用临床医药杂志》
CAS
2020年第10期72-76,共5页
Journal of Clinical Medicine in Practice
基金
陕西省卫生厅科研基金项目(2015JM05689)。
关键词
慢性阻塞性肺疾病
肺间质纤维化
N-乙酰半胱氨酸
罗红霉素
肺功能
chronic obstructive pulmonary disease
pulmonary interstitial fibrosis
N-acetylcysteine
roxithromycin
pulmonary function
