摘要
肠道菌群又被称为人体的"第二基因",是极其复杂的微生态系统。近年来,肠道菌群参与肿瘤免疫的调节备受关注,其在肿瘤的发生和发展中发挥着双重作用。越来越多的研究表明,中医药在肿瘤预防和治疗中发挥着十分重要的作用,尤其在调节肠道菌群和改善肿瘤患者免疫方面效果更加显著。特别值得关注的是,肠道菌群和肿瘤免疫之间存在着非常关键的纽带关系,其可能成为阐释中药抗肿瘤作用机制的新的研究方向。
Intestinal flora,also known as the‘second gene’of human body,is a very complex micro-ecosystem.In recent years,the intestinal flora has attracted much attention in the regulation of tumor immunity,which plays a dual role in the occurrence and development of tumors.It has been found that the intestinal flora of cancer patients,especially those with colorectal cancer,is mostly imbalanced,and imbalanced intestinal flora can affect the occurrence and development of cancer by affecting intestinal metabolism,intestinal homeostasis and intestinal immunity.More and more studies have shown that traditional Chinese medicine plays an important role in cancer prevention and treatment,especially in regulating intestinal flora and improving the immunity of cancer patients.Especially noteworthy is that there is a key link between intestinal flora and tumor immunity,which may become a new research direction to elucidate the anti-tumor mechanism of traditional Chinese medicine.
作者
李瑞晓
李琦
季青
LI Rui-xiao;LI Qi;JI Qing(Department of Oncology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;department of Cancer Institute,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2020年第6期2999-3002,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金资助项目(No.81830120,No.81573749,No.81673783,No.81603457)
上海市科技创新项目(No.14430722900)
上海市优秀学术带头人(No.16XD1403600)
上海市医学领军人才资助项目
上海市中医药三年行动计划(No.ZY-CCCX-2003-03)。
关键词
肠道菌群
肿瘤免疫
中药干预
综述
微生态系统
Intestinal flora
Tumor immunity
Intervention of traditional Chinese medicine
Review
Micro-ecosystem
