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虎杖痛风颗粒治疗急性痛风性关节炎的有效性及安全性研究 被引量:11

Research on the efficacy and safety of Huzhang Tongfeng Granules in the treatment of acute gouty arthritis
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摘要 目的:观察虎杖痛风颗粒治疗急性痛风性关节炎的临床疗效评价及安全性。方法:将132例痛风患者随机分为治疗组(64例)和对照组(68例),治疗组予虎杖痛风颗粒,对照组予尼美舒利分散片,治疗观察1周。观察两组关节功能恢复、病情视觉模拟评分(VAS)、中医症候积分、血尿酸(BUA)、C-反应蛋白(CRP)、血沉(ESR)、白细胞计数(WBC)、谷草转氨酶(AST)、谷丙转氨酶(ALT)、肌酐(Scr)、复发率及不良反应发生率。结果:两组VAS评分及中医临床症候积分治疗后均明显降低(P<0.01),两组治疗前后的差值比较均无显著性差异。治疗后,治疗组BUA、Scr、WBC显著降低(P<0.05,P<0.01)。对照组CRP、ESR、WBC显著降低(P<0.01,P<0.05)。两组治疗前后的AST、ALT比较均无显著性差异。治疗组显效率为82.8%(53/64),总有效率为98.4%(63/64);对照组显效率为80.9%(55/68),总有效率为97.1%(66/68)。结论:虎杖痛风颗粒治疗急性痛风性关节临床疗效确切,安全性好,且具有一定降低BUA以及保护肾脏的作用,对预防复发有积极作用。 Objective:To accomplish the clinical evaluation and safety evaluation of Huzhang Tongfeng Granules in the treatment of acute gouty arthritis.Methods:A total of 132 gout patients were randomly divided into two groups:treatment group in which 64 cases were treated with Huzhang Tongfeng Granules and control group in which 68 cases were treated with Nimesulide dispersible tablets,treatment observation for one week.The joint function,visual analogue scale(VAS),TCM symptom score,blood uric acid(BUA),CRP,ESR,WBC,AST,ALT,Scr,recurrence rate and adverse reaction rate were observed.Results:The VAS scores and TCM symptom scores of the treatment group and the control group were both significantly reduced after treatment(P<0.01),there was no significant difference in the difference between the two groups before and after treatment.After treatment,the BUA,Scr,WBC in the treatment group decreased(P<0.05,P<0.01),CRP,ESR,WBC in the control group decreased(P<0.01,P<0.05).There was no significant difference in AST and ALT between the two groups before and after treatment.The treatment group showed an effective rate of 82.8%(53/64)and the total effective rate is 98.4%(63/64).The control group showed an effective rate of 80.9%(55/68)and the total effective rate is 97.1%(66/68).Conclusion:Huzhang Tongfeng Granules is effective in treating acute gouty arthritis with good safety,and it has a certain role in reducing blood uric acid and protecting the kidneys,also it has a positive effect on preventing recurrence.
作者 周蜜 王一飞 华亮 杨滢瑶 李斌 张明 ZHOU Mi;WANG Yi-fei;HUA Liang;YANG Ying-yao;LI Bin;ZHANG Ming(Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Chinese Medicine,Shanghai 200437,China;Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处 《中华中医药杂志》 CAS CSCD 北大核心 2020年第6期3247-3250,共4页 China Journal of Traditional Chinese Medicine and Pharmacy
基金 国家自然科学基金项目(No.81603627) 上海市进一步加快中医药事业发展三年行动计划(2014年-2016年)资助(No.ZY3-CCCX-1-1008) 上海市进一步加快中医药事业发展三年行动计划(2018年-2020年)资助[No.ZY(2018-2020)-FWTX-4010]。
关键词 虎杖痛风颗粒 急性痛风性关节炎 临床研究 Huzhang Tongfeng Granules Acute gouty arthritis Clinical research
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