摘要
角膜新生血管可继发于多种眼部疾病,是影响角膜透明度的主要原因之一.微小RNA(microRNA,miRNA)与病理性角膜新生血管密切相关,可通过调控多种细胞因子的表达和信号传导途径影响角膜新生血管生成.抑制角膜新生血管的miRNA包括miR-184、miR-204,促进角膜新生血管的miRNA包括miR-126、miR-132、miR-21和miR-27a/b.调控这些miRNA有望成为角膜新生血管的治疗方法.对促进角膜血管新生的miRNA,可使用反义miRNA寡核苷酸antagomir抑制内源性miRNA作用.
Corneal neovascularization(CNV)occurs in many ocular diseases,which is one of the main factors affecting corneal transparency.MicroRNA is closely related to pathological CNV,and can affect the generation of CNV by regulating the expression of various cytokines and signal pathways.It mainly includes miRNA that inhibit CNV(such as miR-184,miR-204)and miRNA that promote CNV(such as miR-126,miR-132,miR-21,and miR-27a/b).Regulation of these miRNAs is expected to be therapentic method for CNV.The antisense miRNA oligonucleotide antigomir can be used to inhibit the endogenous miRNA effect in promoting curred angiogenesis.
作者
陈祖凤
邹俊
Chen Zufeng;Zou Jun(Clinical Medical College of Shanghai Tenth People’s Hospital of Nanjing Medical University,Shanghai 200072,China)
出处
《国际眼科纵览》
2020年第3期192-196,共5页
International Review of Ophthalmology
基金
同济大学中央高校基本科研业务费专项资金(22120170254)。
