摘要
目的观察喜炎平结合单磷酸阿糖腺苷治疗手足口病患儿的临床疗效。方法本次研究对象选取江苏省淮安市洪泽区妇幼保健院儿科2018年7月—2019年7月收治的手足口病患儿90例,数字随机法分成两组,各45例,其中对照组采取喜炎平治疗,观察组基于对照组加用单磷酸阿糖腺苷,比较两组临床疗效及症状消退时间。结果观察组总有效率为95.6%,比对照组77.8%更高;观察组口腔疱疹愈合时间、疱疹消退、退烧时间及住院时间均比于对照组更短;观察组IgA、IgM水平均低于对照组,IgG高于对照组,上述比较均差异有统计学(P<0.05);对照组不良反应发生率为4.4%,观察组为2.2%,差异无统计学意义(P> 0.05)。结论喜炎平结合单磷酸阿糖腺苷治疗手足口病临床疗效优良,可快速改善症状,且安全性较高。
Objective To observe the clinical effect of Xiyanping combined with adenosine monophosphate in the treatment of hand, foot and mouth disease(HFMD). Methods From July 2018 to July 2019, 90 children with HFMD in Hongze District, Huai’an City, Jiangsu Province were randomly divided into two groups, 45 children in each group. The control group was treated with Xiyanping, and the observation group was treated with adenosine monophosphate. The clinical efficacy and symptom regression time of the two groups were compared. Results The total effective rate was 95.6% in the observation group, higher than 77.8% in the control group. The oral herpes healing time, herpes regression, fever reduction time and hospital stay time in the observation group were shorter than those in the control group. The IgA, IgM levels of the observation group were all lower than those of the control group, and IgG was higher than that of the control group, indicating statistically significant differences(P < 0.05). The incidence of adverse reactions was 4.4% in the control group and 2.2% in the observation group, showing no statistical difference(P > 0.05). Conclusion Xiyanping combined with adenosine monophosphate is effective in the treatment of hand, foot and mouth disease. It can improve the symptoms quickly and is safe.
作者
汪泽军
WANG Zejun(Pediatrics Department,Maternal and Child Health Hospital of Hongze District,Huai'an Jiangsu 223100,China)
出处
《中国继续医学教育》
2020年第21期157-159,共3页
China Continuing Medical Education
关键词
喜炎平
单磷酸阿糖腺苷
手足口病
治疗价值
症状消退时间
临床疗效
Xiyanping
vidarabine monophosphate
hand
foot and mouth disease
therapeutic value
symptom resolution time
clinical curative effect
