摘要
目的探讨宫内感染与早产儿肺损伤的相关性。方法回顾性分析广西壮族自治区妇幼保健院2017年1月至2019年1月收治的579例早产儿临床资料,其中发生肺损伤72例,未发生肺损伤507例;根据其母体孕期是否存在宫内感染分为宫内感染组(256例)和非宫内感染组(323例),应用Pearson相关性分析探讨宫内感染与早产儿肺损伤的相关性。结果宫内感染组早产儿暂时性呼吸过快、新生儿肺炎、新生儿呼吸窘迫综合征发生率分别为7.42%(19/256)、9.38%(24/256)和2.73%(7/256),均显著高于非宫内感染组[3.13%(8/323)、4.68%(12/323)和0.78%(2/323)],差异均有统计学意义(χ^2=7.866、7.854、4.187,P均<0.001)。72例发生肺损伤的早产儿中,宫内感染组Murray肺损伤评分[(2.76±0.83)分]高于非宫内感染组[(2.04±0.66)分],差异有统计学意义(t=3.595、P<0.001)。宫内感染组母体炎性因子IL-6和TNF-α水平高于非宫内感染组(t=4.663、3.529,均P<0.001)。将Murray肺损伤评分按照0.45分为1个阶段划分,随着Murray肺损伤评分的增加,宫内感染发生率呈增加的趋势,差异有统计学意义(χ^2=25.402、P<0.001);Pearson相关性分析显示,产妇宫内感染炎性因子IL-6和TNF-α分别与早产儿Murray肺损伤评分呈正相关(r=0.821、0.833,均P<0.001)。结论宫内感染可增加早产儿肺损伤发生率,母体炎因子水平与其早产儿Murray肺损伤评分具有相关性。
Objective To investigate the correlation between intrauterine infection and lung injury of premature infants.Methods The clinical data of 579 premature infants who were admitted to Maternal and Child Health Hospital in Guangxi Zhuang Autonomous Region from January 2017 to January 2019 were analyzed,retrospectively.Among them,72 cases were with lung injury and 507 cases without lung injury.According to presence or absence of maternal intrauterine infection during pregnancy period,they were divided into intrauterine infection group(256 cases)and non-intrauterine infection group(323 cases).The correlation between intrauterine infection and lung injury in premature infants was analyzed by Pearson correlation analysis.Results The incidence rates of transient hyperpnea in premature infants,neonatal pneumonia and neonatal respiratory distress syndrome of intrauterine infection group were significantly higher than those of non-intrauterine infection group[7.42%(19/256),9.38%(24/256),2.73%(7/256)vs.3.13%(8/323),4.68%(12/323),0.78%(2/323)],with significant differences(χ^2=7.866,7.854,4.187,all P<0.001).Among the 72 premature infants with lung injury,Murray lung injury score in intrauterine infection group was higher than that of non-intrauterine infection group[(2.76±0.83)vs.(2.04±0.66)],with significant difference(t=3.595,P<0.001).The levels of maternal inflammatory factors,interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in intrauterine infection group were higher than those of non-intrauterine infection group,with significant differences(t=4.663,3.529;all P<0.001).Murray lung injury score was divided according to 0.45 point as a stage.As Murray lung injury score increasing,the incidence of intrauterine infection increased,with significant differences(χ^2=25.402,P<0.001).Pearson correlation analysis showed that intrauterine infection inflammatory factors(IL-6 and TNF-α)were positively correlated with Murray lung injury score,with significant differences(r=0.821,0.833;all P<0.001).Conclusions Intrauterine infection could result the increased incidence of lung injury in premature infants.The levels of maternal inflammatory factors were associated with Murray lung injury scores in the premature infants.
作者
李凌霄
赵丹
莫艳
Li Lingxiao;Zhao Dan;Mo Yan(Neonatal Pediatrics,Maternal and Child Health Hospital in Guangxi Zhuang Autonomous Region Nanning 530000,China)
出处
《中华实验和临床感染病杂志（电子版）》
CAS
2020年第2期128-132,共5页
Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)
基金
广西壮族自治区卫生和计划生育委员会自筹经费科研课题(No.Z20170789)。
关键词
宫内感染
早产儿
肺损伤
相关性
Intrauterine infection
Premature infant
Lung injury
Correlation
