摘要
目的探讨平喘抗炎胶囊联合沙丁胺醇治疗支气管哮喘的临床疗效。方法选取2017年6月—2019年12月重庆医科大学附属永川医院收治的支气管哮喘患者140例作为研究对象,根据随机数字表法将患者分为对照组和观察组,每组各70例。对照组患者经口吸入硫酸沙丁胺醇气雾剂,0.1 mg/次,4次/d。观察组在对照组患者治疗的基础上口服平喘抗炎胶囊,2粒/次,3次/d。两组连续治疗8周。比较两组患者的临床疗效,对比两组患者的症状改善情况、第一秒用力呼气容积(FEV1)、FEV1预计值、呼气峰值流速(PEF)、细胞间黏附分子-1(ICAM-1)、血清转化生长因子β1(TGF-β1)和白细胞介素-17(IL-17)水平。结果治疗后,观察组患者总有效率为94.29%,明显高于对照组的82.86%(P<0.05)。治疗后,观察组患者的止咳时间、咯痰消失时间、哮鸣音消失时间显著短于对照组,两组比较差异有统计学意义(P<0.05)。两组治疗后的FEV1、FEV1预计值和PEF水平均明显升高,同组治疗前后比较差异具有统计学意义(P<0.05);观察组治疗后的FEV1、FEV1预计值、PEF显著高于对照组,两组比较差异具有统计学意义(P<0.05)。两组治疗后的ICAM-1、TGF-β1、IL-17均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05),且观察组治疗后气道炎症反应指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论平喘抗炎胶囊联合沙丁胺醇治疗支气管哮喘具有较好的临床疗效,可有效降低气道炎症反应,提高肺功能,具有良好的临床研究价值。
Objective To explore the clinical effect of Pingchuan Kangyan Capsules combined with salbutamol in treatment of bronchial asthma.Methods A total of 140 patients with bronchial asthma in Yongchuan Hospital Affiliated to Chongqing Medical University from June 2017 to December 2019 were selected as the research objects.According to the random number table method,the patients were divided into control group and observation group,with 70 patients in each group.Patients in the control group were orally inhaled Salbutamol Sulphate Aerosol,0.1 mg/time,four times daily.Patients in the observation group were po administered with Pingchuan Kangyan Capsules on the basis of control group,2 grains/time,three times daily.Both groups were treated consecutively for 8 weeks.The clinical efficacy of two groups were observed,and the symptom improvement,FEV1,FEV1 predicted value,PEF,and the levels of ICAM-1,TGF-β1,and IL-17 were compared.Results After treatment,the total effective rate was 94.29%in the observation group,which was significantly higher than 82.86%in the control group(P<0.05).After treatment,the time of antitussive,expectoration disappear,and wheezing disappear in the observation group were significantly shorter than those in the control group,and the difference between the two groups was statistically significant(P<0.05).After treatment,FEV1,FEV1 predicted value,and PEF levels in two groups were significantly increased(P<0.05),while FEV1,FEV1 predicted value,and PEF in the observation group were significantly higher than those in the control group(P<0.05).After treatment,the levels of ICAM-1,TGF-β1,and IL-17 in two groups were significantly decreased(P<0.05),and the levels of ICAM-1,TGF-β1,and IL-17 were significantly lower than those in the control group(P<0.05).Conclusion Pingchuan Kangyan Capsules combined with salbutamol has a good clinical effect in treatment of bronchial asthma,which can effectively reduce inflammation and improve lung function,it has good clinical research value.
作者
刘晓莉
姚草原
LIU Xiaoli;YAO Caoyuan(Department of Internal Medicine,Chongqing Yongchuan District Hospital of Traditional Chinese Medicine,Chongqing 402160,China;Department of Respiratory Medicine,Yongchuan Hospital Affiliated to Chongqing Medical University,Chongqing 402160,China)
出处
《药物评价研究》
CAS
2020年第7期1371-1374,共4页
Drug Evaluation Research
