摘要
目的:探讨营养干预对局部晚期鼻咽癌患者在放化疗期间的营养状态及体质量的影响。方法:选取我院2015年1月-2019年12月收治的112例鼻咽癌晚期患者,按随机数表法分成营养干预组和对照组各56例,均采用同一放化疗治疗方案,观察组在此基础上给予营养干预。对比两组患者在放化疗治疗期间的生活质量(QOL)评分、营养状态、黏膜损害程度、体质量变化和近期疗效。结果:放射剂量达40Gy时,营养干预组QOL评分≥41分的比例显著高于对照组(P<0.05);放疗结束后营养干预组发生Ⅲ级以上的口腔黏膜损害的患者比例显著低于对照组(P<0.05);放化疗第4周营养干预组的体质量显著高于对照组(P<0.05);放化疗治疗结束后两组原发灶残余比例和淋巴结转移比例比较均无统计学差异(P>0.05);放化疗第4、7周营养干预组的血红蛋白(Hb)、总蛋白(TP)和白蛋白(Alb)显著高于对照组(P<0.05)。结论:鼻咽癌患者在放化疗期间,营养状况下降明显,营养干预治疗能够有效改善患者的体质量和营养状况,对于患者的后续治疗具有重要意义,应在晚期鼻咽癌的临床治疗中推广营养干预。
Objective: To investigate the impact of nutrition intervention on body weight and nutrition status of patients with locally advanced nasopharyngeal carcinoma during chemoradiotherapy. Methods: 112 cases of patients with advanced nasopharyngeal carcinoma(NPC) treated in our hospital from January 2015 to December 2019 were selected and divided into nutrition intervention group and control group according to the stochastic indicator method, with 56 cases in each group. They were treated by the same chemoradiotherapy treatment, and patients of observation group were treated with nutrition intervention on this basis. The quality of life scores(QOL score), nutritional status, mucosa damage, quality change and recent curative effect of two groups of patients were compared during chemoradiotherapy. Results: When the radiation dose was 40 gy, the proportion of patients with QOL score 41 in the nutritional intervention group was 87.5%(49/56), which was significantly higher than that 55.4%(31/56) in control group(P<0.05). After radiotherapy, the proportion of patients in the nutrition intervention group with oral mucosa damage above grade III was significantly lower than that in the control group(P<0.05). The body weight of the patients in nutritional intervention group were significantly higher than that of patients in control group in the 4 th week of chemoradiotherapy(P<0.05). There was no significant difference in residual proportion of primary tumor and lymph node metastasis between the two groups after chemoradiotherapy(P>0.05). And in the 4 th and7 th week, the hemoglobin(Hb), total protein(TP) and albumin(Alb) of nutritional intervention group were significantly higher than those of the conrol group(P<0.05). Conclusion: During chemoradiotherapy, the nutrition states of patients with nasopharyngeal carcinoma decreased significantly. Nutritional intervention can effectively improve the patient’s body weight and nutrition, which is of great significance for the follow-up treatment.The nutrition intervention should be promoted in the clinical treatment of advanced nasopharyngeal carcinoma.
作者
黄小妹
吴宏
李嘉雯
周密
吴迪军
HUANG Xiao-mei;WU Hong;LI Jia-wen;ZHOU Mi;WU Di-jun(Department of Radiotherapy,The Second Affiliated Hospital of Nantong University/Nantong First People's Hospital,Nantong,Jiangsu,226001,China;Department of Hepatobiliary Surgery,The Second Affiliated Hospital of Nantong University/Nantong First People's Hospital,Nantong,Jiangsu,226001,China;Hanlin College of Nanjing University of Traditional Chinese Medicine,Nanjing,Jiangsu,210000,China)
出处
《现代生物医学进展》
CAS
2020年第12期2317-2320,2324,共5页
Progress in Modern Biomedicine
基金
江苏省卫生计生委医学科研面上项目(H20161457)。
关键词
营养干预
鼻咽癌
放化疗
体质量
营养状态
Nutrition intervention
Nasopharyngeal carcinoma
Chemoradiotherapy
Body weight
Nutritional status
