摘要
目的探讨益肤透明质酸凝胶配合复方甘草酸苷治疗过敏性皮肤病的疗效及对外周血T淋巴细胞平衡的影响。方法纳入2017年3月至2018年7月本院皮肤科收治的130例过敏性皮肤病患者作为研究对象,参照随机数字表法分为观察组(65例)和对照组(65例)。观察组采用透明质酸凝胶联合复方甘草酸苷治疗,对照组口服西替利嗪片治疗。观察两组患者临床疗效、皮肤指标、T细胞亚群分布及不良反应发生情况。结果观察组总有效率为90.77%,明显高于对照组的73.85%,差异有统计学意义(P<0.05);两组治疗1周、2周及4周后经皮水分散失评分均低于治疗前(P<0.05),观察组明显低于对照组(P<0.05);两组治疗1、2及4周后角质层含水量评分均高于治疗前(P<0.05),观察组明显高于对照组(P<0.05);观察组患者CD3^+、CD4^+及CD4^+/CD8^+明显高于对照组(P<0.05),CD8^+淋巴细胞明显低于对照组(P<0.05);观察组患者不良反应发生率为9.23%,略低于对照组的15.38%,差异无统计学意义(P>0.05)。结论益肤透明质酸凝胶配合复方甘草酸苷治疗过敏性皮肤病可有效改善患者皮肤功能,纠正T淋巴细胞亚群紊乱,不良反应少,安全且有效。
Objective To investigate the effect of Yifu hyaluronic acid gel combined with compound glycyrrhizin in the treatment of allergic dermatosis and its influence on peripheral blood T lymphatic balance.Methods A total of 130 patients with allergic dermatosis admitted to dermatology department of our hospital from March 2017 to July 2018 were selected as the study subjects,they were divided into observation group(n=65)and control group(n=65)with random number table.The observation group was treated with hyaluronic acid gel combined with compound glycyrrhizin,while the control group was given cetirizine tablets.The clinical efficacy,skin index,distribution of T lymphocyte subsets and the occurrence of adverse reactions were observed.Results The total efficiency of the observation group was 90.77%,which was statistically higher than that of the control group(73.85%,P<0.05).The trans epidermal water loss score of the both groups after 1,2,and 4 weeks of treatment were lower than those before treatment(P<0.05),while that in the observation group was lower than that in the control group(P<0.05).Cuticle water content score of the both groups after 1,2,and 4 weeks of treatment were higher than those before treatment(P<0.05),while that in the observation group was significantly higher than that in the control group(P<0.05).The levels of CD3^+,CD4^+,CD4^+/CD8^+ in the observation group were significantly higher than those in the control group(P<0.05).The level of CD8^+ lymphocyte in the observation group was significantly lower than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was 9.23%,which was slightly lower than the control group(15.38%),but there was no significant difference(P>0.05).Conclusion Yifu hyaluronic acid gel combined with compound glycyrrhizin in treating allergic dermatosis can effectively improve the skin function of patients,correcting the disorder of T lymphocyte subsets,and have fewer adverse reactions,which is more safe and effective.
作者
吴春燕
白方树
徐晓静
WU Chun-yan;BAI Fang-shu;XU Xiao-jing(Department of Dermatology,Beijing Changping District Hospital of Traditional Chinese Medicine,Beijing 102200,China)
出处
《世界临床药物》
CAS
2020年第6期451-455,共5页
World Clinical Drug
