摘要
目的通过Meta分析的方法探讨阿奇霉素联合盐酸氨溴索治疗小儿支原体肺炎的疗效,为临床上治疗小儿支原体肺炎的合理用药提供科学依据。方法通过中国知网(CNKI)、万方医学网、中国科学引文数据库,Pubmed和Embase数据库,检索阿奇霉素联合盐酸氨溴索治疗小儿支原体肺炎的相关研究,检索时限自建库起截至2020年1月15日。使用Stata 12.0软件对纳入研究的文献进行Meta分析。结果共纳入了13篇文献,病例1404例,其中观察组734例,对照组670例。Meta分析结果显示,阿奇霉素联合盐酸氨溴索治疗小儿支原体肺炎的疗效显著优于单独使用阿奇霉素(OR=0.21,95%CI:0.15~0.30,P<0.001),可缩短退热时间(SMD=-1.37,95%CI:-1.80^-0.95,P<0.001)、咳嗽喘憋缓解时间(SMD=-1.33,95%CI:-.84^-0.82,P<0.001)、肺部啰音消失时间(SMD=-1.46,95%CI:-1.96^-0.96,P<0.001)。结论阿奇霉素联合盐酸氨溴索治疗小儿支原体肺炎可显著提高疗效。
Objective To evaluate the efficacy of azithromycin combined with ambroxol hydrochioride in the treatment of mycoplasmal pneumonia in children by a meta-analysis,in order to provide a scientific basis for the rational use of mycoplasma pneumonia in children.Methods Relevant studies on child mycoplasmal pneumonia treated by azithromycin combined with ambroxol hydrochioride were retrieved from China National Knowledge Index(CNKI),Wangfang Medical Database,Chinese Science Citation Database(CSCD),Pubmed,and Embase.And the retrieved deadline was January 15,2020.Meta-analysis was performed by using Stata 12.0 software.Results A total of 13 studies were included,including 1404 cases,among which there were 734 cases in the observation group and 670 cases in the control group.The results of Meta-analysis indicated that azithromycin combined with ambroxol hydrochioride can treat mycoplasma pneumonia in children better than azithromycin alone(OR=0.21,95%CI:0.15~0.30,P<0.001),which can significantly reduce the disappearance time of antipyretic(SMD=-1.37,95%CI:-1.80^-0.95,P<0.001),cough and asthma(SMD=-1.33,95%CI:-1.84^-0.82,P<0.001),pulmonary rales(SMD=-1.46,95%CI:-1.96^-0.96,P<0.001).Conclusion Azithromycin combined with ambroxol hydrochioride in the treatment of mycoplasma pneumonia in children can significantly improve the curative effect.
作者
杨扬
王星雨
金来润
Yang Yang;Wang Xingyu;Jin Lairun(School of Humanities and Management,Wannan Medical College,Wuhu,Anhui 241002,China)
出处
《湘南学院学报（医学版）》
2020年第2期9-12,共4页
Journal of Xiangnan University（Medical Sciences）
关键词
阿奇霉素
盐酸氨溴索
儿童
支原体肺炎
META分析
azithromycin
ambroxol hydrochioride
children
mycoplasmal pneumonia
meta-analysis
