摘要
本文合成了三种具有多氢键的联萘酚轴手性硫脲催化剂,并将其用于催化合成1,4-二氢吡啶衍生物。结果显示,所合成的新型多氢键硫脲均表现出较好的催化作用,能有效地提高1,4-二氢吡啶衍生物的收率和对映选择性。所有新化合物结构均经过1H NMR、13C NMR、IR、熔点等表征所确认。
Three kinds of structure-symmetric thiourea catalysts containing multi-hydrogen bond with binol axial chiral were synthesized and successfully applied to the syntheses of 1,4-dihydropyridine derivatives.The results showed that the synthesized polyhydrogen-bonded thioureas have better catalytic activity,which can effectively improve the yield and enantioselectivity of the 1,4-dihydropyridine derivatives.All new compounds were characterized by 1H NMR、13C NMR、IR、melting point and so on.
作者
秦婷
莫丽
陈平平
安雪婕
陈治明
Qin Ting;Mo Li;Chen Pingping;An Xuejie;Chen Zhiming(Key Laboratory of Functional Materials Chemistry of Guizhou Province,School of Chemistry and Materials Science,Guizhou Normal University,Guiyang,550001)
出处
《化学通报》
CAS
CSCD
北大核心
2020年第7期665-671,共7页
Chemistry
基金
国家自然科学基金项目(21362006)资助。
关键词
催化剂
1
4-二氢吡啶
硫脲
合成
Catalyst
1,4-Dihydropyridine
Thiourea
Synthesis
