摘要
阿司匹林通过抑制环氧化酶阻断血栓烷A 2生成而发挥抗血小板聚集作用。已有临床证据证明阿司匹林可减少冠状动脉急性事件发生,起到心血管疾病一级预防作用。阿司匹林的心血管疾病二级预防地位已得到肯定,一级预防作用尚存在争议。现对近期有关阿司匹林在一级预防的试验和进展进行综述,以期为临床阿司匹林应用提供参考。
Aspirin can inhibit platelet aggregation by inhibiting the production of thromboxane A2 by cyclooxygenase.There is clinical evidence that aspirin can reduce the occurrence of acute coronary events and play a primary role in the prevention of cardiovascular disease.At present,the secondary prevention status of aspirin for cardiovascular disease has been confirmed,and the primary prevention effect is still controversial.This article reviews the evidence of primary cardiovascular prophylaxis with aspirin in recent years,with a view to provide relevant reference for aspirin in clinical application.
作者
何斌
张冬颖
HE Bin;ZHANG Dongying(Department of Cardiology,The First Affiliated Hospital of Chongqing Medical Universiy,Chongqing 400016,China)
出处
《心血管病学进展》
CAS
2020年第6期627-629,637,共4页
Advances in Cardiovascular Diseases
关键词
心血管疾病
阿司匹林
一级预防
Cardiovascular disease
Aspirin
Primary prevention
