摘要
目的观察2型糖尿病肾病患者应用硫辛酸治疗后氧化应激和足细胞标志蛋白(PCX)、明胶酶相关载脂蛋白(NGAI)、足细胞裂孔膜蛋白(nephrin)水平的变化。方法选取2016年3月—2019年3月河北大学附属医院肾内二科诊治2型糖尿病肾病患者80例作为研究对象,应用奇、偶数法分为2组。对照组40例予常规药物方案治疗,观察组40例在对照组治疗方案基础上予以硫辛酸治疗,比较2组PCX、NGAI、nephrin水平以及肾功能指标、氧化应激指标、炎性因子水平差异。结果治疗后,观察组血清肌酐(SCr)和尿白蛋白排泄率(UAFR)低于对照组(t=5.583、19.738,P均=0.000);F2-异前列腺素类化合物(PGF2)、丙二醛(MDA)、硝基酪氨酸(NT)水平低于对照组(t=29.316、35.976、9.125,P均=0.000);治疗后2组PCX和nephrin均升高,NGAI均降低,且观察组升高/降低幅度大于对照组(t=4.339、8.102、13.440,P均=0.000);治疗后2组高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平均降低,且观察组低于对照组(t=6.010、8.751、3.835,P均=0.000)。结论2型糖尿病肾病患者在接受常规方案治疗的同时辅以硫辛酸治疗,能够促进肾功能恢复,减轻氧化应激反应、炎性反应及足细胞损伤,效果显著。
Objective To observe the changes of oxdative stress,podocyte marker protein(PCX),gelatinase related apolipoprotein and podocyte hiatal membrane protein in patients with type 2 diabetic nephropathy after treatment with lipoic acid.Methods From March 2016 to March 2019,80 patients with type 2 diabetic nephropathy were selected as the research objects.They were divided into two groups by odd and even number method.40 cases in the control group were treated with conventional drug regimen.40 cases in the observation group were treated with lipoic acid on the basis of the control group.The levels of PCX,gelatinase related apolipoprotein,podocyte pore membrane protein,renal function indexes,oxidative stress indexes and inflammatory factors were compared between the two groups.Results After treatment,the serum creatinine and urinary albumin excretion rates of the observation group were lower than those of the control group(t=5.583,19.738,P=0.000),and the levels of F2 isoprostanes,MDA and NT in the observation group were lower than those in the control group(t=29.316,35.976,9.125,all P=0.000).After treatment,PCX and podocyte pore membrane protein increased and gelatinase related apolipoprotein decreased in both groups,and the increase/decrease range of observation group was greater than that of control group(t=4.339,8.102,13.440,all P=0.000).After treatment,the levels of high-sensitivity C-reactive protein,tumor necrosis factorαand interleukin-6 in the two groups were decreased,and the observation group was lower than the control group(t=6.010,8.751,3.835,all P=0.000).Conclusion Patients with type 2 diabetic nephropathy received conventional treatment combined with lipoic acid treatment,which can promote the recovery of renal function,reduce oxidative stress reaction,inflammatory response and podocyte damage,with significant effect.
作者
李敬
樊星
高燕
张丽敏
杜伟轩
王倩
Li Jing;Fan Xing;Gao Yan;Zhang Limin;Du Weixuan;Wang Qian(Department of Nephrology, Affiliated Hospital of Hebei University, Hebei Province, Baoding 071000,China)
出处
《疑难病杂志》
CAS
2020年第8期774-777,共4页
Chinese Journal of Difficult and Complicated Cases
关键词
2型糖尿病肾病
硫辛酸
氧化应激反应
足细胞标志蛋白
明胶酶相关载脂蛋白
足细胞裂孔膜蛋白
Type 2 diabetic nephropathy
Lipoic acid
Oxidative stress
Podocyte marker protein
Gelatinase related apolipoproteins
Podocyte pore membrane protein expression
