摘要
目的:观察经颅直流电刺激(transcranial direct current stimulation,tDCS)联合柴胡加龙骨牡蛎汤治疗卒中后抑郁症(post stroke depression,PSD)的疗效和安全性。方法:将63例脑卒中后抑郁症患者按随机数字表法分为tDCS联合柴胡加龙骨牡蛎汤组(治疗组)31例和tDCS组(对照组)32例,治疗组在tDCS治疗基础上口服柴胡加龙骨牡蛎汤,对照组给予tDCS治疗,1mA直流电流强度刺激患者左侧额叶背外侧,每日1次,每次30 min,连续治疗2周为1个疗程。2组患者在治疗前和治疗后1、2、4周末分别采用HAMD(汉密尔顿抑郁量表)进行抑郁评分,通过对比前后评分、临床疗效来判断对PSD的治疗效果。结果:治疗组HAMD评分在治疗期间持续降低,疗效可持续到停止治疗后的第4周,与治疗前比较差异有统计学意义。对照组治疗后第1周和治疗前比较差异有统计学意义,随后HAMD评分逐渐升高,与治疗前比较差异无统计学意义,2组未观察到明显的不良反应。结论:tDCS联合柴胡加龙骨牡蛎汤是一种新颖的治疗模式,经本研究证实对PSD具有确切的治疗效果且无不良反应。
Objective:To study the efficacy and safety of transcranial direct current stimulation(tDCS)combined with Chaihu Plus Longgu Muli Decoction in post stroke depression.Methods:63 patients with post-stroke depression were randomly assigned to a treatment group(31 cases)and a control group(32 cases).The conventional symptomatic and supportive treatment in neurological internal medicine was applied to all of the cases in two groups.Two groups was treated with transcranial direct current stimulation.Left prefrontal lobe was applied with 1mA stimulation for 30 minutes a day,The treatment lasted for 2 weeks.The treatment group was combined with Chaihu Plus Longgu Muli Decoction.Hamilton Depression Scale(HAMD)and efficacy were compared between two groups.Results:After treatment,HAMD score was reduced remarkably as compared with that before treatment in treatment group at 1 week and 2weeks,and the efficacy was continued to 4 weeks.HAMD score was reduced after 1 week in control group.and gradually increased.No special side effects occur in the patients.Conclusion:Transcranial direct current stimulation combined Chaihu Plus Longgu Muli Decoction can improve depressive state of patients with PSD.
作者
郑一
高玉红
李光善
ZHENG Yi;GAO Yu-hong;Li Guang-shan(Dongying Shengli Hospital,Shandong,Dongying 257055,China;Tingdao Hospital of Traditional Chinese Medicine,Shandong,Qingdao 266033,China)
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2020年第7期947-949,共3页
JOURNAL OF BASIC CHINESE MEDICINE
基金
第四批全国中医(临床、基础)优秀人才研修项目(国中医药人教发[2017]24号)。
