摘要
目的:探讨高原环境对胎盘成熟度、脐动脉血流动力学及妊娠结局的影响。方法:收集2017年7月-2018年12月本院产前检查分娩的来自高原地区孕妇78例为观察组,平原地区孕妇67例对照组。根据Grannum标准对两组胎盘成熟度分级,彩色多普勒超声测定两组子宫动脉及脐动脉血管收缩期峰速(PS)、舒张期流速(PD)、S/D阻力指数(RI)、搏动指数(PI);随访到分娩结束,记录两组新生儿体质量、胎盘质量及胎盘体积;采用SPSS Pearson相关性分析对高原环境与胎盘成熟度、脐动脉血流动力学及妊娠结局进行相关性分析。结果:观察组胎盘成熟度II级、III级比例高于对照组,子宫动脉血PS水平低于对照组(P<0.05),两组PD、S/D、RI、PI水平比较无差异(P>0.05);观察组脐动脉血PD水平低于对照组,S/D、RI水平高于对照组,新生儿体质量、胎盘重量、胎盘体积均小于对照组(P<0.05);高原环境与胎盘成熟度呈正相关性,与脐动脉血流动力学及妊娠结局呈负相关性(P<0.05)。结论:高原环境能引起脐动脉血流动力学减少,加速胎盘成熟老化,影响妊娠结局,提示应予以重视并加强胎儿监测与治疗,促进胎儿生长发育。
Objective:To investigate the effects of altitude environment on placental maturity,umbilical arterial hemodynamics,and pregnancy outcomes.Methods:78 pregnant women from the plateau area were selected in observation group,and 67 pregnant women from the plain area were selected in control group from July 2017 to December 2018.The maturity degree of placenta of women in the two groups was graded according to the Grannum criteria.The systolic peak velocity(PS),diastolic flow rate(PD),S/D resistance index(RI),and pulsatility index(PI)of the uterine artery and umbilical artery of women in the two groups were measured by color Doppler ultrasound.The women in both groups were followed up until the end of delivery,and the neonatal body weight,and the placental weight and volume of women in the two groups were recorded.Pearson correlation analysis in SPSS software was used for analyzing correlation between the plateau environment and placental maturity,umbilical cord arterial hemodynamics,or pregnancy outcomes.Results:The proportion of the maturity grade II and III of placenta of women in the observation group was significant higher than that of women in the control group(P<0.05),but the value of the PS of uterine arterial blood of women in the observation group was significant lower(P<0.05).There were no significant difference in the values of PD,S/D,RI and PI of women between the two groups(P>0.05).The value of PD of umbilical artery blood,the neonatal body weight,and the placental weight and volume of women in the observation group were significant less than that of women in the control group,but the values of S/D and RI of women in the observation group were significant higher.Correlation analysis showed that plateau environment was positively correlated with placental maturity grade,but was negatively correlated with the values of umbilical artery hemodynamics and pregnancy outcomes of women(P<0.05).Conclusion:The plateau environment can reduce the hemodynamics of umbilical arteries,accelerate the early maturity and aging of the placenta,and had adverse affect on pregnancy outcomes,so fetal monitoring and treatment under the guidance by doctors for promoting fetal growth and development should be strengthen.
作者
宋熲
杨卓加
SONG Jiong;YANG Zhuojia(Hospital Affiliated to Qinghai University, Xining, Qinghai Province, 810000)
出处
《中国计划生育学杂志》
2020年第5期702-705,共4页
Chinese Journal of Family Planning
关键词
高原环境
胎盘成熟度
脐动脉血流动力学
妊娠结局
Plateau environment
Placental maturity
Umbilical artery hemodynamics
Pregnancy outcomes
