摘要
目的探讨阿立哌唑治疗癫痫所致精神障碍患者的临床效果。方法选取我院2018年1~12月收治的60例癫痫所致精神障碍患者作为研究对象,按照掷骰子方法分为实验组与对照组,各30例,对照组采用奋乃静抗精神病药物治疗方法,实验组采用阿立哌唑治疗方法。比较两组的临床疗效,治疗前后阳性与阴性症状量表(PANSS)评分、简易智力状态检查量表(MMSE)评分、汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分以及生命质量评分。结果实验组的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。两组的治疗前PANSS评分比较,差异无统计学意义(P>0.05);实验组治疗后的一般精神病理评分、阳性症状评分、阴性症状评分及总分低于对照组,差异均有统计学意义(P<0.05)。实验组治疗后的MMSE、生命质量评分高于对照组,HAMA、HAMD评分低于对照组,差异均有统计学意义(P<0.05)。结论癫痫所致精神障碍患者应用阿立哌唑治疗效果更高,而且可以有效改善患者的症状体征,改善患者的智力状态以及心理状态,提升患者的生活质量。
Objective To investigate the clinical effect of Aripiprazole in the treatment of epileptic mental disorders.Methods From January to December in 2018,60 epileptic patients with mental disorders were selected as the research objects,and divided into experimental group and control group according to the dice rolling method,each had 30 cases.The control group was treated with Perphenazine and the experimental group with Aripiprazole.The clinical efficacy,positive and negative symptoms scale(PANSS)score,mini-mental tate examination scale(MMSE)score,Hamilton Anxiety Scale(HAMA)score,Hamilton depression scale(HAMD)and quality of life score of the two groups were compared before and after treatment.Results The total effective rate of the experimental group was higher than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in PANSS between the two groups before treatment(P>0.05).After treatment,the scores of general psychopathology,positive symptoms,negative symptoms and total scores in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the scores of MMSE and quality of life in the experimental group were higher than those in the control group,and the scores of HAMA and HAMD were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion Aripiprazole is more effective in the treatment of mental disorders caused by epilepsy,and it can effectively improve the symptoms and signs of patients,improve the mental state and mental state of patients,and improve the quality of life of patients.
作者
马春丽
徐甜颖
MA Chun-li;XU Tian-ying(The First Department of Neurology,the Second Affiliated Hospital of Mudanjiang Medical College,Heilongjiang Province,Mudanjiang 157000,China)
出处
《中国当代医药》
2020年第21期79-81,共3页
China Modern Medicine
