摘要
目的探究金纳多联合多奈哌齐治疗脑卒中后认知功能障碍的临床疗效。方法选取2018年4月至2019年9月本院收治的缺血性脑卒中后认知功能障碍患者104例,按照治疗方案的不同将对象随机分为治疗组(n=54)及对照组(n=50)。治疗组予以金纳多联合多奈哌齐治疗,对照组仅予多奈哌齐治疗,两组均连续治疗4周。观察两组临床疗效,并采用Barthel指数(BI)、蒙特利尔认知评估量表(MoCA)、简易精神状态量表(MMSE)评定患者生活质量、认知功能。结果治疗前,两组患者MMSE、MoCA、BI评分比较,差异均无统计学意义(均P>0.05);治疗后,治疗组MMSE、MoCA、BI评分分别为(28.97±3.10)分、(27.28±2.61)分、(73.50±8.29)分,均高于对照组(26.41±2.75)分、(24.40±2.32)分、(67.71±7.11)分,差异均有统计学意义(均P<0.05);治疗组总有效率为94.44%(51/54),明显高于对照组78.00%(39/50),差异有统计学意义(均P<0.05)。结论金纳多联合多奈哌齐能够有效改善脑卒中后患者的认知功能。
Objective To investigate the efficacy of ginaton combined with donepezil in the treatment of post-stroke cognitive dysfunction.Methods 104 patients with post-stroke cognitive dysfunction admitted into our hospital from April,2018 to September,2019 were randomly divided into a treatment group(n=54)and a control group(n=50).The treatment group was treated with ginaton and donepezil,while control group with donepezil,for 4 weeks.The Barthel Index(BI),Montreal Cognitive Assessment(MoCA),and Mini-Mental State Examination(MMSE)were used to assess their life quality and cognitive function.Results There were no statistical differences in the scores of MMSE,MoCA,and BI between two groups(all P>0.05).After the treatment,the scores of MMSE,MoCA,and BI were higher in the treatment group than in the control group[(28.97±3.10)vs.(26.41±2.75),(27.28±2.61)vs.(24.40±2.32),and(73.50±8.29)vs.(67.71±7.11);all P<0.05].The clinical efficacy of the treatment group was better than that of the control group(94.44%vs.78.00%,P<0.05).Conclusion Ginaton combined with donepezil can effectively improve the cognitive function of stroke patients.
作者
秦荣凤
郭炜
韩峰
温婷
Qin Rongfeng;Guo Wei;Han Feng;Wen Ting(Department of Rehabilitation,Qingdao Fuwai Cardiovascular Hospital,Qingdao 266034,China)
出处
《国际医药卫生导报》
2020年第16期2395-2397,共3页
International Medicine and Health Guidance News
