摘要
目的探究多囊卵巢综合征(PCOS)患者血清肾上腺源性雄激素(DHEAS)、血管生成素样蛋白2(Angptl2)、结缔组织生长因子(CTGF)水平变化及其与胰岛素抵抗指数(HOMR-IR)、体质指数(BMI)的相关性。方法选取2017年1月至2019年9月长治市人民医院收治的200例PCOS患者为研究组,另选取同期197例健康体检者作为对照组。比较两组DHEAS、Angptl2、CTGF、HOMR-IR、BMI水平,采用Logistic回归分析各指标与PCOS的关系。分析研究组不同HOMR-IR、BMI患者血清DHEAS、Angptl2、CTGF,Pearson指标与HOMR-IR、BMI的相关性。结果研究组HOMR-IR、BMI及血清DHEAS、Angptl2、CTGF水平高于对照组(P<0.05)。HOMR-IR、BMI及血清DHEAS、Angptl2、CTGF水平与PCOS密切相关(P<0.05)。研究组HOMR-IR≥2.57者血清DHEAS、Angptl2、CTGF水平高于HOMR-IR<2.57者(P<0.05);研究组BMI≥25 kg/m2者血清DHEAS、Angptl2、CTGF水平高于BMI<25 kg/m2者(P<0.05);血清DHEAS、Angptl2、CTGF水平与HOMR-IR、BMI呈正相关(P<0.05)。结论PCOS患者血清DHEAS、Angptl2、CTGF高表达,HOMR-IR、BMI升高,且二者存在正相关关系,检测血清DHEAS、Angptl2、CTGF对治疗及改善HOMR-IR、BMI具有意义。
Objective To investigate the levels of adrenergic androgen(DHEAS),angiopoietin like protein 2(Angptl2),connective tissue growth factor(CTGF),and their correlations with homeostatic model assessment for insulin resistance(HOMR-IR)and body mass index(BMI)in patients with polycystic ovary syndrome(PCOS).Methods A total of 200 PCOS patients treated in Changzhi People’s Hospital from January 2017 to September 2019 were selected as the study group,and 197 healthy persons who had physical examination were selected as the control group in the same period.The levels of DHEAS,Angptl2,CTGF,HOMR-IR and BMI were compared between the two groups,and the relationships of these indexes with PCOS were analyzed by logistic regression.The correlations of serum DHEAS,Angptl2,CTGF and Pearson indicators with HOMR-IR and BMI in patients with different HOMR-IR and BMI in the study group were analyzed.Results The levels of HOMR-IR,BMI,serum DHEAS,Angptl2 and CTGF in the study group were higher than those in the control group(P<0.05).HOMR-IR,BMI and levels of serum DHEAS,Angptl2,CTGF were closely related to PCOS(P<0.05).The levels of serum DHEAS,Angptl2 and CTGF in patients with HOMR-IR≥2.57 were higher than patients with HOMR-IR<2.57 in the study group(P<0.05).Serum DHEAS,Angptl2 and CTGF in patients with BMI≥25 kg/m2 in the study group were higher than patients with BMI<25 kg/m2(P<0.05).Levels of serum DHEAS,Angptl2 and CTGF were positively correlated with HOMR-IR and BMI(P<0.05).Conclusions The levels of serum DHEAS,Angptl2,CTGF,and HOMR-IR,BMI in PCOS patients are elevated,and the levels of DHEAS,Angptl2,CTGF have positive correlation with HOMR-IR and BMI.The detection of serum DHEAS,Angptl2,CTGF has significance for the treatment and improvement of HOMR-IR and BMI.
作者
孙晓玲
Sun Xiaoling(Department of Gynecology,Changzhi People’s Hospital,Changzhi 046000,China)
出处
《中国实用医刊》
2020年第9期79-83,共5页
Chinese Journal of Practical Medicine
