摘要
【目的】探讨血清脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)水平变化与冠心病(CHD)患者病情严重程度的相关性。【方法】选取2015年1月至2017年12月本院收治的120例CHD患者为观察组、同期健康体检的60例健康志愿者为对照组。检测两组血清Vaspin、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)水平,并分析CHD患者血清Vaspin与冠脉病变程度的相关性,采用Logistic回归分析发生CHD的高危因素。【结果】观察组患者血清TG、TC、HDL-C、LDL-C、FPG显著高于对照组,血清Vaspin水平低于对照组,差异均有统计学意义(P<0.05)。中度狭窄组、重度狭窄组患者的血清Vaspin水平低于轻度狭窄组,重度狭窄组低于中度狭窄组,差异均有统计学意义(F=22.198,P<0.05)。观察组患者Gensini评分为(60.55±13.91)分,血清Vaspin与Gensini评分呈显著负相关性(r=-0.692,P<0.05)。Logistic多因素回归分析显示,血清Vaspin、HDL-C水平降低,TC、TG、LDL-C水平升高是发生CHD的独立危险因素(P<0.05)。【结论】CHD患者血清Vaspin水平显著降低,且血清Vaspin水平与CHD患者冠脉病变程度呈显著负相关性。
【Objective】To investigate the correlation between serum Vaspin level and severity of coronary heart disease(CHD).【Methods】A total of 120 patients with CHD in our hospital from January 2015 to December 2017 were selected as the observation group and 60 healthy volunteers in the same period as the control group.Serum Vaspin,triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)and fasting blood glucose(FPG)were detected in the two groups.The correlation between serum vaspin and the severity of coronary artery disease was analyzed.The high-risk factors of CHD were analyzed by logistic regression.【Results】The serum TG,TC,HDL-C,LDL-C and FPG of the observation group were significantly higher than those of the control group,and the serum Vaspin level was lower than that of the control group(P<0.05).The serum Vaspin level of moderate stenosis group and severe stenosis group was lower than that of the mild stenosis group,and that of the severe stenosis group was lower than that of the moderate stenosis group(F=22.198,P<0.05).The Gensini score of the observation group was(60.55±13.91),and there was a significant negative correlation between serum vaspin and Gensini score(r=-0.692,P<0.05).Logistic regression analysis showed that the decrease of serum Vaspin and HDL-C levels,and the increase of TC,TG and LDL-C levels were the independent risk factors for CHD(P<0.05).【Conclusion】The serum Vaspin level was significantly lower in CHD patients,and the serum vaspin level is negatively correlated with the severity of coronary artery disease in CHD patients.
作者
徐虹
许亚男
王涛
XU Hong;XU Ya-nan;WANG Tao(Shandong Provincial Third Hospital,Jinan 250031)
出处
《医学临床研究》
CAS
2020年第7期986-988,共3页
Journal of Clinical Research
基金
山东省医药科技发展计划项目(2018WS287)。
