摘要
目的:探讨地黄益智颗粒干预遗忘型轻度认知损害(aMCI)患者向痴呆转化的临床疗效。方法:选取肾精亏虚兼痰瘀阻络证aMCI患者86例,随机分为对照组与治疗组,每组各43例。治疗组采用地黄益智颗粒治疗,对照组采用茴拉西坦胶囊治疗,两组治疗周期均为24周。治疗前后,比较两组患者的简易精神状态检查(MMSE)量表、蒙特利尔认知评估(MoCA)量表、日常生活活动能力(ADL)量表、照顾者负担(ZBI)量表的评分及中医证候积分的变化;治疗结束后随访1年,比较两组患者的阿尔茨海默病(AD)转化率。结果:治疗后,两组患者的MMSE、MoCA评分较治疗前均升高(P<0.05),且治疗组患者的MMSE评分高于对照组(P<0.05)。治疗后,两组患者的ZBI、ADL评分及中医证候积分较治疗前均降低(P<0.01),且治疗组患者的ZBI、ADL评分及中医证候积分均低于对照组(P<0.01)。随访中,治疗组患者的AD转化率为7.89%,对照组为12.50%,治疗组的AD转化率低于对照组(P<0.05)。结论:地黄益智颗粒干预aMCI,可显著改善患者的记忆和认知能力,提高生活质量,同时延缓疾病向痴呆转化的进程。
Objective:To explore the clinical efficacy of Dihuang Yizhi Granule on the conversion from amnestic mild cognitive impairment(aMCI)to dementia.Methods:Eighty-six patients of aMCI with syndromes of kidney essence deficiency and phlegm and blood stasis blocking collaterals were selected and randomly divided into the control group and the treatment group,43 cases in each group.The patients in the treatment group were treated with Dihuang Yizhi Granule and the patients in the control group were treated with aniracetam capsule,with a course of 24 weeks.Before and after treatment,the scores of mini-mental state examination(MMSE)scale,Montreal cognitive assessment(MoCA)scale,activity of daily living(ADL)scale,Zarit caregiver burden interview(ZBI)scale and Chinese medical syndrome were compared between the two groups.The patients were followed-up for one year after treatment,and the conversion rate of Alzheimer’s disease(AD)was compared between the two groups.Results:After treatment,the scores of MMSE and MoC A in both groups were increased compared with those before treatment(P<0.05),and the score of MMSE in the treatment group was higher than that in the control group(P<0.05).After treatment,the scores of ZBI,ADL and Chinese medical syndrome in both groups were decreased compared with those before treatment(P<0.01),and the scores of ZBI,ADL and Chinese medical syndrome in the treatment group were lower than those in the control group(P<0.01).During the follow-up,the conversion rates of AD in the treatment group and the control group were 7.89%and 12.50%respectively,and the conversion rate of AD in the treatment group was lower than that in the control group(P<0.05).Conclusion:Dihuang Yizhi Granule can significantly improve the memory and cognitive ability of patients with aM CI,enhance the quality of life,and delay the conversion to dementia.
作者
顾超
安红梅
袁灿兴
闫建汶
GU Chao;AN Hongmei;YUAN Canxing;YAN Jianwen(Department of Neurology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Tibet Disease Diagnosis and Treatment Centre of Integrated Chinese and Western Medicine,Xikaze 857000,Tibet,China;Department of Integrated Chinese and Western Medicine,Xikaze People's Hospital,Xikaze 857000,Tibet,China)
出处
《上海中医药大学学报》
CAS
2020年第4期7-10,20,共5页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
国家重点研发计划重大慢性非传染性疾病防控研究重点专项项目(2017YFC1310300)
上海市科委科技创新行动计划国内科技合作领域项目(19695840100)
上海市“医苑新星”青年医学人才培养资助计划项目(沪卫人事[2020]087号)
西藏自治区自然科学基金组团式医学援藏项目[XZ2019ZR-ZY47(Z)]。
关键词
遗忘型轻度认知损害
痴呆
地黄益智颗粒
中医药疗法
amnestic mild cognitive impairment
dementia
Dihuang Yizhi Granule
Chinese medical therapy
