摘要
目的探讨老年人动脉瘤性蛛网膜下腔出血继发癫痫的相关因素。方法选取武汉市中医医院2015年1月至2019年1月收治的老年动脉瘤性蛛网膜下腔出血患者213例,根据是否继发癫痫分为癫痫组46例与无癫痫组167例。采用单因素分析影响老年人动脉瘤性蛛网膜下腔出血继发癫痫的相关因素,采用多因素logistic回归分析影响老年人动脉瘤性蛛网膜下腔出血继发癫痫危险因素。结果单因素分析结果显示,两组性别、年龄、合并糖尿病和吸烟史差异均无统计学意义(均P>0.05);癫痫组与无癫痫组合并高血压(15例比22例)、责任动脉瘤位于大脑中动脉(22例比24例)、动脉瘤数量多发(23例比41例)、颅内血肿(15例比26例)、脑积水(15例比21例)和神经功能后遗症(14例比20例)差异均有统计学意义(χ^2=9.491、23.840、11.113、6.737、10.306、9.161,均P<0.05)。多因素分析结果显示,合并高血压、动脉瘤位于大脑中动脉、多发动脉瘤、颅内血肿、脑积水和神经功能后遗症为影响老年人动脉瘤性蛛网膜下腔出血继发癫痫危险因素[OR(95%CI)分别为2.361(1.476~3.421)、3.012(1.935~1.845)、1.494(1.027~1.845)、2.785(1.684~3.982)、1.920(1.283~2.984)、1.637(1.171~2.316)]。结论老年人动脉瘤性蛛网膜下腔出血继发癫痫影响因素较多,为降低继发癫痫发生,应针对上述危险因素采取预防措施。
Objective To explore the related factors of epilepsy secondary to aneurysmal subarachnoid hemorrhage in the elderly.Methods From January 2015 to January 2019,213 elderly patients with aneurysmal subarachnoid hemorrhage admitted to Wuhan Hospital of Traditional Chinese Medicine were divided into epilepsy group(46 cases)and non-epilepsy group(167 cases)according to whether secondary epilepsy.Univariate analysis was used to analyze the related factors affecting epilepsy secondary to aneurysmal subarachnoid hemorrhage in the elderly,and multivariate logistic regression was used to analyze the risk factors of epilepsy secondary to aneurysmal subarachnoid hemorrhage in the elderly.The investigation factors included sex,age,hypertension,diabetes mellitus,smoking history,location of responsible aneurysms,number of aneurysms,intracranial hematoma,hydrocephalus and neurological sequelae.Results Univariate analysis showed that there were no statistically significant differences in sex,age,history of diabetes mellitus and smoking between the two groups(all P>0.05).There were statistically significant differences between the epilepsy group and non epilepsy group in hypertension(15 cases vs.22 cases),location of responsible aneurysms in middle cerebral artery(22 cases vs.24 cases),number of aneurysms(23 cases vs.41 cases),intracranial hematoma(15 cases vs.26 cases),hydrocephalus(15 cases vs.21 cases)and neurological sequelae(14 cases vs.20 cases)(χ^2=9.491,23.840,11.113,6.737,10.306,9.161,all P<0.05).The results of multivariate analysis showed that hypertension,middle cerebral artery,multiple aneurysms,intracranial hematoma,hydrocephalus and neurologic sequelae were risk factors for epilepsy secondary to aneurysmal subarachnoid hemorrhage in the elderly[OR(95%CI)2.361(1.476-3.421),3.012(1.935-1.845),1.494(1.027-1.845),2.785(1.684-3.982),1.920(1.283-2.984),1.637(1.171-2.316)].Conclusion There are many factors influencing secondary epilepsy in elderly patients with aneurysmal subarachnoid hemorrhage.In order to reduce the incidence of secondary epilepsy,preventive measures should be taken against the above risk factors.
作者
张军
李汉永
罗卫东
熊妍
喻灿
李旭成
Zhang Jun;Li Hanyong;Luo Weidong;Xiong Yan;Yu Can;Li Xucheng(Department of Critical Medicine,Wuhan Hospital of Traditional Chinese Medicine,Wuhan,Hubei 430000,China)
出处
《中国基层医药》
CAS
2020年第15期1849-1852,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
动脉瘤
蛛网膜下腔出血
癫痫
高血压
大脑中动脉
颅内出血
脑积水
老年人
因素分析
统计学
Aneurysm
Subarachnoid hemorrhage
Epilepsy
Hypertension
Middle cerebral artery
Intracranial hemorrhages
Hydrocephalus
Aged
Factor analysis
statistical
