摘要
目的探讨赖氨葡锌颗粒联合消旋卡多曲治疗小儿轮状病毒性肠炎的临床疗效及对心肌酶指标的影响。方法选取2018年7月至2019年7月温州市人民医院收治的轮状病毒性肠炎患儿110例为研究对象,按照随机数字表法分为对照组和研究组,每组55例。对照组患儿给予消旋卡多曲颗粒治疗,研究组患儿给予赖氨葡锌颗粒联合消旋卡多曲颗粒治疗。两组疗程均为7 d。记录治疗期间药物不良反应,统计患儿腹泻停止时间、发热消退时间、呕吐停止时间及住院时间,分别于治疗前后检测患儿血清心肌酶含量,评价患儿的疗效。结果研究组腹泻停止时间、发热消退时间、呕吐停止时间及住院时间[(2.61±0.69)d、(1.31±0.48)d、(2.17±0.54)d、(4.03±0.82)d]均显著短于对照组[(3.84±0.82)d、(2.76±0.63)d、(3.39±0.71)d、(5.42±1.07)d],差异均有统计学意义(t=6.207、8.154、7.316、5.593,均P<0.05)。研究组总有效率为94.54%(52/55),显著高于对照组的80.00%(44/55),差异有统计学意义(χ^2=5.238,P<0.05)。研究组治疗后血清磷酸肌酸激酶、磷酸肌酸激酶同功酶和乳酸脱氢酶含量[(35.02±5.36)U/L、(92.83±9.62)U/L、(112.09±12.73)U/L]均显著低于对照组[(46.54±6.93)U/L、(118.36±10.83)U/L、(118.36±10.83)U/L],差异均有统计学意义(t=7.629、10.637、9.592,均P<0.05)。治疗期间,两组患儿恶心、便秘、皮疹和嗜睡等药物不良反应发生率差异无统计学意义[9.09%(5/55)比10.91%(6/55),χ^2=0.101,P=0.751]。结论与消旋卡多曲单独治疗比较,赖氨葡锌颗粒联合消旋卡多曲可有效缩短轮状病毒性肠炎患儿临床症状改善时间,提高总体疗效,降低心肌损伤程度,且不增加不良反应。
Objective To explore the clinical effect of lysine hydrochloride and zinc gluconate granules combined with racecadotril in the treatment of rotavirus enteritis in children and its effect on myocardial enzymes.Methods From July 2018 to July 2019,110 children with rotavirus enteritis in the People's Hospital of Wenzhou were selected in the research.All the children were divided into control group and study group according to random number table method,with 55 cases in each group.The control group was treated with racecadotril granules,while the study group was treated with lysine hydrochloride and zinc gluconate granules combined with racecadotril granules.The adverse drug reactions were recorded during the treatment.The diarrhea stopping time,fever subsidence time,vomiting stopping time and hospitalization time were recorded.The patients were examined before and after treatment.The levels of serum myocardial enzymes were measured to evaluate the therapeutic effect of rotavirus enteritis in children.Results The diarrhea stopping time,fever subsidence time,vomiting stopping time and hospitalization time in the study group[(2.61±0.69)d,(1.31±0.48)d,(2.17±0.54)d,(4.03±0.82)d]were significantly shorter than those in the control group[(3.84±0.82)d,(2.76±0.63)d,(3.39±0.71)d,(5.42±1.07)d],the differences were statistically significant(t=6.207,8.154,7.316,5.593,all P<0.05).The total effective rate of treatment for rotavirus enteritis in the study group[94.54%(52/55)]was significantly higher than that in the control group[80.00%(44/55)],the difference was statistically significant(χ^2=5.238,P<0.05).The levels of serum CK,CK-MB and LDH in the study group[(35.02±5.36)U/L,(92.83±9.62)U/L,(112.09±12.73)U/L]were significantly lower than those in the control group[(46.54±6.93)U/L,(118.36±10.83)U/L,(118.36±10.83)U/L]after treatment,the differences were statistically significant(t=7.629,10.637,9.592,all P<0.05).During treatment,the overall incidence of adverse drug reactions such as nausea,abdominal pain,rash and sleepiness between the two groups had no statistically significant difference[9.09%(5/55)vs.10.91%(6/55),χ^2=0.101,P=0.751].Conclusion Compared with racecadotril alone,lysine hydrochloride and zinc gluconate granules combined with racecadotril can effectively shorten the improvement time of clinical symptoms in children with rotavirus enteritis,improve the overall curative effect,reduce the degree of myocardial injury,and does not increase adverse drug reactions,which is worthy of clinical application.
作者
纪菲菲
Ji Feifei(Department of Pediatrics,the People's Hospital of Wenzhou(Wenzhou Women's and Children's Hospital),Wenzhou,Zhejiang 325000,China)
出处
《中国基层医药》
CAS
2020年第15期1853-1857,共5页
Chinese Journal of Primary Medicine and Pharmacy
关键词
轮状病毒感染
肠炎
消旋卡多曲
赖氨葡锌颗粒
肌酸激酶
肌酸激酶
MB型
乳酸脱氢酶类
儿童
Rotavirus infections
Enteritis
Racecadotril
Lysine and zinc gluconate granules
Creatine kinase
Creatine kinase
MB form
Lactate dehydrogenases
Child
