摘要
目的探讨穴位贴敷联合补肾益气固冲安胎汤辅助治疗肾虚型先兆流产的临床疗效。方法选取2018年6月至2019年2月温州市中医院收治的先兆流产患者80例,中医辨证分型均为肾虚型,将其按照随机数字表法分为对照组和观察组,每组40例。对照组给予黄体酮注射液治疗,观察组在对照组基础上给予穴位贴敷联合补肾益气固冲安胎汤治疗,两组均治疗2周。观察两组治疗前后临床症状改善情况,检测两组治疗前后性激素水平[血清孕酮(P)、雌二醇(E2)、人绒毛膜促性腺激素(β-HCG)、孕激素诱导阻滞因子(PIBF)]水平,并检测两组治疗前后淋巴免疫细胞,同时对两组的临床疗效进行评估。结果治疗后两组阴道出血、腰骶酸痛、出血时间、倦怠乏力症状评分及总评分均较治疗前显著下降(t≥29.780,均P<0.05),但观察组下降均更为明显(t=11.655、10.864、8.898、11.910、17.415,均P<0.05)。观察组总有效率为95.00%(38/40),显著高于对照组的70.00%(28/40),差异有统计学意义(χ^2=5.854,P<0.05)。治疗后两组P、E2、β-HCG、PIBF水平均显著升高(t≥5.507,均P<0.05),但观察组升高均更为明显(t=6.358、16.297、112.692、3.262,均P<0.05)。治疗后观察组CD4+、NK水平均较治疗前显著下降(t=12.538、4.520,均P<0.05),CD8+水平显著高于治疗前(t=6.982,P<0.05),但对照组治疗前后差异均无统计学意义(t=0.769、1.594、1.292,均P>0.05)。结论穴位贴敷联合补肾益气固冲安胎汤辅助治疗可以显著改善先兆流产患者的临床症状,临床效果好,其机制可能与调节孕妇激素水平及免疫因子状态有关。
Objective To explore the clinical effects of acupoint sticking combined with Bushen Yiqi and Guchong Antai decoction in the treatment of threatened abortion with kidney deficiency.Methods From June 2018 to February 2019,80 patients with threatened abortion and kidney deficiency type in Wenzhou Hospital of Traditional Chinese Medicine were selected and divided into observation group and control group according to the random digital table method,with 40 cases in each group.The control group was given progesterone injection,while the observation group received acupoint sticking combined with Bushen Yiqi and Guchong Antai decoction on the basis of the control group.Both two groups were treated for 2 weeks.Before and after treatment,the improvement of clinical symptoms,the levels of sex hormones[serum progesterone(P),estradiol(E 2),human chorionic gonadotropin(β-HCG),progester-one-induced blockade factor(PIBF)]and lymph immune cells were recorded and compared in the two groups,and the clinical efficacy was evaluated.Results After treatment,the vaginal bleeding,lumbosacral soreness,bleeding time,burnout symptoms and total scores in the two groups were all decreased significantly compared with those before treatment(t≥29.780,all P<0.05),which of the observation group decreased more significantly(t=11.655,10.864,8.898,1.910,17.415,all P<0.055).The total effective rate in the observation group was 95.00%(38/40),which was significantly higher than 70.00%(28/40)in the control group(χ^2=5.854,P<0.05).After treatment,the levels of P,E 2,β-HCG and PIBF increased significantly in the two groups(t≥5.507,all P<0.05),but the increasing degrees in the observation group were more significant(t=6.358,16.297,112.692,3.262,all P<0.05).After treatment,the levels of CD+4 and NK in the observation group were significantly lower than those before treatment(t=12.538,4.520,all P<0.05),and the level of CD+8 in the observation group was significantly higher than that before treatment(t=6.982,P<0.05),but the above indicators in the control group before and after treatment had no statistically significant differences(t=0.769,1.594,1.292,all P>0.05).Conclusion Acupoint sticking combined with Bushen Yiqi and Guchong Antai decoction can significantly improve the clinical symptoms of threatened abortion women,which has better clinical effects,and its mechanism may be related to the regulation of hormone levels and chronic inflammatory status in pregnant women.
作者
郑慧君
孙云
马大正
Zheng Huijun;Sun Yun;Ma Dazheng(Department of Traditional Chinese Medicine and Gynecology,Wenzhou Hospital of Traditional Chinese Medicine,Wenzhou,Zhejiang 325000,China)
出处
《中国基层医药》
CAS
2020年第14期1698-1702,共5页
Chinese Journal of Primary Medicine and Pharmacy
关键词
流产
先兆
透皮贴剂
穴位
中草药
医学
中国传统
性腺激素类
淋巴细胞
Abortion
threatened
Transdermal patch
Acupoint
Drugs
Chinese herbal
Medicine
Chinese traditional
Gonadal hormones
Lymphocytes
