摘要
目的:探讨肾神经内分泌肿瘤的临床特征和治疗方法。方法:本文报道了1例38岁的男性患者,2004年因右肾占位行"右侧根治性肾切除术",术后病理显示右肾神经内分泌肿瘤。手术后患者未接受任何抗肿瘤治疗。2015年1月,患者出现腹部和腹膜后转移,然后在全身麻醉下于2015年3月4日进行腹部肿瘤切除,肿瘤的大小约为20 cm×8 cm×5 cm,位于下腔静脉及腹主动脉之间,后方达脊柱前缘。术后病理显示神经内分泌肿瘤G2(非典型类癌),该患者被诊断为复发性右肾神经内分泌肿瘤。奥沙利铂加卡培他滨方案于2015年5月27日开始。经过2个疗程评估后,腹膜后肿瘤再次出现。结果:因患者生长抑素受体显像结果呈阳性,因此我们将治疗方案改为醋酸奥曲肽20 mg肌肉注射,每4周一次,目前已接受29次注射,患者目前一般状况可,多次复查结果评为病情稳定(SD)。结论:肾神经内分泌肿瘤罕见,对于术后或化疗后复发的患者,可从生长抑素类似物治疗中获益。
Objective:To investigate the clinical features and treatment of renal neuroendocrine neoplasm.Methods:A 38-year-old male patient was reported in this article.In 2004,he underwent right radical nephrectomy due to right kidney occupation.Postoperative pathology revealed a neuroendocrine neoplasm of the right kidney.The patient did not receive any anti-tumor treatment after the operation.In January 2015,the patient developed metastasis to the abdomen and retroperitoneum,and then underwent general anesthesia to perform abdominal tumor resection on March 4,2015.The size of the tumor was about 20 cm×8 cm×5 cm,which was located between the inferior vena cava and abdominal aorta,reaching the anterior edge of the spine.Postoperative pathology showed a neuroendocrine neoplasm G2(atypical carcinoid tumor),and the patient was diagnosed with a recurrent neuroendocrine neoplasm of the right kidney.The oxaliplatin plus capecitabine program began on May 27,2015.After 2 courses of evaluation,the retroperitoneal neoplasm reappeared.Results:Because the patient’s somatostatin receptor imaging result was positive,we changed the treatment regimen to 20 mg intramuscular injection of octreotide acetate,every 4 weeks.Up to now,he has received 29 injections.The current general condition of the patient is yes.Repeated review results were rated as stable disease(SD).Conclusion:Renal neuroendocrine neoplasms are rare,and patients who relapse after surgery or after chemotherapy can benefit from somatostatin analog therapy.
作者
祁亮
沈洁
刘宝瑞
邹征云
Qi Liang;Shen Jie;Liu Baorui;Zou Zhengyun(The Comprehensive Cancer Centre of Drum Tower Hospital,Medical School of Nanjing University&Clinical Cancer Institute of Nanjing University,Jiangsu Nanjing 210008,China)
出处
《现代肿瘤医学》
CAS
2020年第17期2999-3003,共5页
Journal of Modern Oncology
关键词
肾神经内分泌肿瘤
奥曲肽微球
案例报道
renal neuroendocrine neoplasms
octreotide microspheres
case report
