摘要
目的 探讨首发精神分裂症患者精神病未治期(DUP)及其他临床因素对疾病预后的影响.方法 以104例首发精神分裂症患者为研究对象,按照出院随访1年时的功能大体评定量表(GAF)评分将患者分为预后良好组(GP组,GAF>60分,n=57)和预后不良组(PP组,GAF≤60分,n=47),比较2组临床资料的差异.对首发精神分裂症患者预后的影响因素进行多因素Logistic回归分析.结果 GP组中精神病学家族史阳性率、阳性症状及急性起病患者的比例低于PP组,DUP低于PP组,差异均有统计学意义(P<0.05).随访1年后发现,与PP组相比,GP组首次住院治疗效果较好,坚持服药的患者比例更高,且复发率较低(P<0.05).多因素Logistic回归分析显示:症状表现、起病的缓急及DUP均是首发精神分裂症患者预后的影响因素(P<0.05).结论 急性起病,以阳性症状为主要表现,且DUP短的首发精神分裂症患者预后较好.
Objective To investigate the influence of duration of untreated psychosis(DUP)and other clinical factors on the prognosis of first-episode schizophrenia.Methods A total of 104 first-episode schizophrenic patients were divided into a group with good prognosis(GP group,GAF>60 points,n=57)and a group with poor prognosis(PP group,GAF≤60 points,n=47)according to the gross rating scale(GAF)score of 1 year follow-up after discharge.The prognostic factors of first-episode schizophrenia were analyzed by multivariate Logistic regression.Results The positive rate of family history of psychiatry,the proportion of positive symptoms and acute onset of illness in the GP group was lower than that in the PP group,and DUP was lower in the GP group than that in the PP group,with statistically significant differences(P<0.05).After 1 year follow-up,it was found that,compared with PP group,GP group had a better effect of first hospitalization,a higher proportion of patients insisted on taking medicine,and a lower recurrence rate(P<0.05).Multivariate Logistic regression analysis showed that symptoms,onset delay and DUP were all factors influencing the prognosis of first-episode schizophrenia patients(P<0.05).Conclusions The acute onset of schizophrenia is mainly manifested by positive symptoms,and the prognosis of first-episode schizophrenia patients with short DUP is better.
作者
潘多
陶睿
王金亮
何孔亮
李智勇
靳胜春
PAN Duo;TAO Rui;WANG Jinliang;HE Kongliang;LI Zhiyong;JIN Shengchun(The Affiliated Psychological Hospital of Anhui Medical University;Anhui Mental Health Center;The Fourth People′s Hospital of Hefei City)
出处
《徐州医科大学学报》
CAS
2020年第8期604-607,共4页
Journal of Xuzhou Medical University
基金
2018年合肥市卫生计生应用医学研究项目(hwk2018zc005)。
关键词
首发精神分裂症
预后
精神病未治期
影响因素
first-episode schizophrenia
prognosis
untreated period of psychosis
influencing factors
