摘要
目的探讨应用低频重复经颅磁刺激治疗精神分裂症的临床有效性。方法方便选取2015年2月—2018年12月该院收治的60例精神分裂症患者随机数字表分组。精神分裂症常规药物治疗组进行精神分裂症常规药物治疗,低频重复经颅磁刺激辅助组进行精神分裂症常规药物+低频重复经颅磁刺激治疗。分析比较两组效果;幻听量表评分降低50%的时间、阳性和阴性症状量表降低50%的时间;治疗前后患者幻听量表评分AHRS、认知功能MMSE评分、阳性和阴性症状量表PANSS评分和生活质量评分;并发症。结果低频重复经颅磁刺激辅助组治疗效果更高,差异有统计学意义(χ^2=10.588,P<0.05)。精神分裂症常规药物治疗组总疗效是70.00%,低频重复经颅磁刺激辅助组100.00%。治疗前两组幻听量表评分AHRS、认知功能MMSE评分、阳性和阴性症状量表PANSS评分和生活质量评分相似,差异无统计学意义(P>0.05);治疗后低频重复经颅磁刺激辅助组幻听量表评分AHRS、认知功能MMSE评分、阳性和阴性症状量表PANSS评分和生活质量评分(4.46±0.21)分、(27.46±2.31)分、(41.46±4.31)分、(94.66±2.22)分优于精神分裂症常规药物治疗组,差异有统计学意义(t=7.911、5.213、8.034、8.944,P<0.05)。低频重复经颅磁刺激辅助组幻听量表评分降低50%的时间,阳性和阴性症状量表降低50%的时间优于精神分裂症常规药物治疗组,差异有统计学意义(t=5.211、6.721,P<0.05)。结论精神分裂症患者行精神分裂症常规药物+低频重复经颅磁刺激治疗效果确切,可进一步改善患者的精神症状和幻听症状,改善生活质量。
Objective To explore the clinical effectiveness of low-frequency repeated transcranial magnetic stimulation in the treatment of schizophrenia.Methods A random number table grouping of 60 patients with schizophrenia admitted from February 2015 to December 2018 was convenient selection collected.The conventional drug treatment group of schizophrenia was treated with conventional drug treatment of schizophrenia,and the auxiliary group of low frequency repeated transcranial magnetic stimulation was treated with the conventional drug of schizophrenia+low frequency repeated transcranial magnetic stimulation.Analyze and compare the effects of the two groups;the time when the hallucination hallmark score was reduced by 50%,and the time for the positive and negative symptom scale was reduced by 50%;before and after treatment,the patient's hallucination hallmark score AHRS,cognitive function MMSE score,positive and negative symptoms table PANSS score and quality of life score;complications.Results The treatment group with low frequency repetitive transcranial magnetic stimulation was more effective,the difference was statistically significant(χ^2=10.588,P<0.05).The total efficacy of the schizophrenia conventional drug treatment group was 70.00%,and the low frequency repetitive transcranial magnetic stimulation auxiliary group was 100.00%.Before the treatment,the auditory hallucination scale score AHRS,cognitive function MMSE score,positive and negative symptom scale PANSS score and quality of life score were similar,no statistically significant difference(P>0.05);after treatment,the low frequency repeated transcranial magnetic stimulation auxiliary group hallucination scale score AHRS,cognitive function MMSE score,positive and negative symptom scale PANSS score and quality of life score(4.46±0.21)points,(27.46±2.31)points,(41.46±4.31)points,(94.66±2.22)points are better than the conventional drug treatment group of schizophrenia,the difference was statistically significant(t=7.911,5.213,8.034,8.944,P<0.05).Low-frequency repetitive transcranial magnetic stimulation auxiliary group reduced the hallucination scale score by 50%,and the positive and negative symptom scale by 50%.It was better than the conventional drug treatment group of schizophrenia,the difference was statistically significant(t=5.211,6.721,P<0.05).Conclusion The treatment of schizophrenia patients with conventional schizophrenia drugs+low-frequency repetitive transcranial magnetic stimulation treatment has a definite effect,which can further improve the patients'mental symptoms and auditory hallucination symptoms,and improve the quality of life.
作者
茅冬琴
MAO Dong-qin(Department of Psychiatry,Fourth People's Hospital of Rudong County,Nantong,Jiangsu Province,226400 China)
出处
《中外医疗》
2020年第18期1-3,10,共4页
China & Foreign Medical Treatment
关键词
低频重复经颅磁刺激
精神分裂症
临床有效性
Low frequency repetitive transcranial magnetic stimulation
Schizophrenia
Clinical effectiveness
