摘要
目的分析上海市适龄女性人乳头瘤病毒(HPV)疫苗接种率和疑似预防接种异常反应发生率。方法通过上海市免疫规划信息系统和中国AEFI监测信息管理系统收集2017年11月-2019年12月上海市9-45岁女性2价HPV疫苗(HPV2)、4价HPV疫苗(HPV4)和9价HPV疫苗(HPV9)的接种剂次数和AEFI发生例数,描述性分析HPV疫苗接种率和AEFI报告发生率。结果2017年11月-2019年12月上海市9-45岁女性共接种HPV疫苗63.43万剂次,其中HPV2、HPV4和HPV9分别占7.5%、58.3%和34.2%。HPV疫苗首剂、全程接种率分别为4.19%、2.83%;各年龄组首剂、全程接种率范围分别为0.39%-7.97%、0.11%-4.25%。HPV疫苗AEFI总报告发生率为256.35/10万剂(1626例),其中一般反应、异常反应分别为249.57/10万剂(1583例)、5.04/10万剂(32例),分别以接种部位红肿(720例,113.51/10万剂)和过敏性皮疹(32例,5.04/10万剂)为主。结论上海市适龄女性HPV疫苗接种率较低,不良反应发生率在预期范围内且严重反应罕见。
Objective To estimate coverage of human papillomavirus(HPV)vaccine and the incidence of adverse event following immunization(AEFI)with HPV vaccine among age-eligible women in Shanghai.Methods We collected HPV vaccination and AEFI data on 9-45-year-old women who had received 2-valent HPV vaccine(HPV2),4-valent HPV vaccine(HPV4),or 9-valent HPV vaccine(HPV9)from November 2017 to December 2019 in Shanghai through the Shanghai Immunization Program Information System and the China AEFI Surveillance Information Management System.We conducted descriptive analyses of vaccination coverage and AEFI incidence.Results A total of 634.3 thousand doses of HPV vaccine were administered to 9-45-year-old women from November 2017 to December 2019 in Shanghai,of which HPV2,HPV4,and HPV9 accounted for 7.5%,58.3%,and 34.2%,respectively.First-dose coverage and full-series coverage were 4.19%and 2.83%,respectively,ranging 0.39%to 7.97%and 0.11%to 4.25%by age group.The overall AEFI incidence was 256.35 per 100000 doses(1626 AEFIs).The incidence per 100000 doses was 249.57(1583)for common adverse reaction and 5.04(32)for rare adverse reactions.Most common adverse reactions were injection-site redness/swelling(720 cases,113.51 per 100000);all rare adverse reactions were anaphylactic rash(32 cases,5.04 per 100000).Conclusion Coverage of HPV vaccine was low among 9-45-year-old women in Shanghai.The incidence of adverse reactions was less than expected and serious reactions were rare.
作者
刘捷宸
吴琳琳
白庆瑞
任佳
邵慧勇
黄卓英
Liu Jiechen;Wu Linlin;Bai Qingrui;Ren Jia;Shao Huiyong;Huang Zhuoying(Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China)
出处
《中国疫苗和免疫》
北大核心
2020年第3期322-325,348,共5页
Chinese Journal of Vaccines and Immunization
关键词
人乳头瘤病毒疫苗
接种率
疑似预防接种异常反应
监测
Human papillomavirus vaccine
Coverage
Adverse event following immunization
Surveillance
