摘要
目的:探讨C反应蛋白(CRP)、心肌肌钙蛋白T(cTnT)、胸腺基质淋巴细胞生成素(TSLP)、miR-30c-5p水平与稳定型心绞痛(SAP)患者冠状动脉病变严重程度的关系。方法:回顾性分析2016年5月至2019年5月间医院收治的经冠状动脉造影(CAG)证实的90例SAP患者的临床资料,根据SYNTAX评分分为轻度组(0~22分,41例)、中度组(23~32分,32例)、重度组(≥33分,17例)。收集三组患者的临床资料,采血检测三组患者的CRP、cTnT、TSLP、miR-30c-5p水平,三组患者的冠状动脉病变严重程度用SYNTAX评分评估,用Pearson相关性分析CRP、cTnT、TSLP、miR-30c-5p水平与SYNTAX评分的关系。结果:三组患者的CRP、cTnT、TSLP、miR-30c-5p水平及SYNTAX评分比较,差异均具有统计学意义(P均<0.05),两两对比LSD-t检验,差异均具有统计学意义(P均<0.05)。Pearson相关性分析显示,CRP、cTnT、TSLP与SYNTAX评分均呈显著正相关(P<0.01),而miR-30c-5p与SYNTAX评分呈显著负相关(P<0.01)。结论:CRP、cTnT、TSLP、miR-30c-5p水平与稳定型心绞痛患者冠状动脉病变严重程度存在相关性,早期检测以上生物学标志物有助于判断稳定性心绞痛患者的冠状动脉病变严重程度。
Objective:To investigate the relationship between the levels of C-reactive protein(CRP),serum troponin T(cTnT),thymic stromal lymphopoietin(TSLP),miR-30c-5p and the severity of coronary artery disease in patients with stable angina pectoris(SAP).Methods:The clinical data of 90 SAP patients confirmed by coronary angiography(CAG)admitted to the hospital from May 2016 to May 2019 were retrospectively analyzed.They were divided into mild groups according to SYNTAX score(0~22 points,41 cases).,Moderate group(23~32 points,32 cases),Severe group(≥33 points,17 cases).Collect clinical data of three groups of patients,collect blood to measure the CRP,cTnT,TSLP,miR-30c-5p levels of the three groups of patients.The severity of coronary artery disease in the three groups of patients was evaluated by SYNTAX score,and CRP,cTnT,Relationship between TSLP,miR-30c-5p levels and SYNTAX score.Results:The CRP,cTnT,TSLP,miR-30c-5p levels,and SYNTAX scores of the three groups of patients were statistically significant(P all<0.05).Pairwise comparisons of LSD-t tests showed statistically significant differences(P all<0.05).Pearson correlation analysis showed that CRP,cTnT,TSLP and SYNTAX scores were significantly positively correlated(P<0.01),while miR-30c-5p was significantly negatively correlated with SYNTAX scores(P<0.01).Conclusion:CRP,cTnT,TSLP,miR-30c-5p levels correlate with the severity of coronary artery disease in patients with stable angina pectoris.Early detection of the above biological markers can help determine the severity of coronary artery disease in patients with stable angina pectoris.
作者
黄玉冰
廖旺
王苗
王裕岱
HUANG Yubing;LIAO Wang;WANG Miao(People's Hospital of Hainan Province / Hainan Hospital Affiliated to Hainan Medical College, Hainan Haikou 570311, China)
出处
《河北医学》
CAS
2020年第8期1255-1259,共5页
Hebei Medicine
基金
海南省科学技术厅项目,(编号:814319)。
