摘要
以NiCl2为催化剂催化N-四氢异喹啉的分子氧氧化脱氢偶联反应,以较高产率制备了一系列N-芳基四氢异喹啉化合物.该方法对不同的N-四氢异喹啉衍生物和亲核试剂均具有较好的适用性,反应均能以较高的产率获得相应的目标产物.与已有方法相比,本方法采用分子氧为氧化剂,具有反应条件温和、底物适用范围广、操作简便等优点,为四氢异喹啉衍生物的制备提供了一种有效途径.
An nickel-catalyzed aerobic cross-dehydrogenative coupling of N-aryl tetrahydroisoquinolines is presented.The catalytic system could tolerate various N-aryl tetrahydroquinoline derivatives and nucleophiles,and the target products could be obtained in good to excellent yields.Compared with reported methods,the protocol uses molecular oxygen as a sustainable oxidant,and provides an effective approach to the synthesis of tetrahydroisoquinoline derivatives under mild and practical conditions.
作者
王慧
王安玮
夏珍珍
周维友
孙中华
钱俊峰
何明阳
Wang Hui;Wang Anwei;Xia Zhenzhen;Zhou Weiyou;Sun Zhonghua;Qian Junfeng;He Mingyang(Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology,School of Petrochemical Engineering,Changzhou University,Changzhou,Jiangsu 213164)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2020年第7期2099-2107,共9页
Chinese Journal of Organic Chemistry
基金
江苏省绿色催化材料与技术重点实验室基金(No.BM2012110)
江苏省研究生科研与实践创新计划(No.KYCX19_1746)
江苏省自然科学基金(No.BK20181461)资助项目.
关键词
脱氢偶联
C—H活化
镍
分子氧
N-芳基四氢异喹啉
cross-dehydrogenative coupling
C—H activation
nickel
molecular oxygen
N-aryl tetrahydroisoquinoline
