摘要
目的探讨扶正固本化瘀汤足浴对糖尿病周围神经病变患者临床症状及神经传导功能的改善效果。方法选择2016年11月-2019年1月医院接受治疗的118例糖尿病周围神经病变患者,根据随机数表法将其分为观察组与对照组,各59例。两组均给予基础抗血糖治疗,同时对照组给予甲钴胺,观察组在此基础上加用扶正固本化瘀汤足浴,比较两组炎症因子[核转录因子-kB(NF-kB)、白细胞介素-6(IL-6)]、临床症状积分、神经传导功能[运动传导速度(MNCV)、感觉传导速度(SNCV)]、血液流变学指标(纤维蛋白原、血浆黏度、红细胞积压)、生活质量评分。结果观察组治疗后,NF-kB、IL-6水平均低于对照组,四肢疼痛、四肢发凉、肢软无力、肢软麻木、感觉减退、肌肉萎缩积分与总积分比对照组低,正中神经MNCV与SNCV、腓总神经MNCV与SNCV均高于对照组,纤维蛋白原、血浆黏度与红细胞积压均低于对照组,生理功能、精神与心理、社会关系、治疗评分及总分均低于对照组,差异有统计学意义(P<0.05)。结论扶正固本化瘀汤足浴可降低糖尿病周围神经病变患者体内炎症因子水平,缓解四肢疼痛、发凉等临床症状,提高神经传导功能,改善血液流变学指标,提高生活质量。
Objective To investigate the effect of Fuzheng Guben Huayu decoction for foot bath on clinical symptoms and nerve conduction function in patients with diabetic peripheral neuropathy.Methods A total of 118 patients with diabetic peripheral neuropathy who received treatment in our hospital from November 2016 to January 2019 were divided into observation group(n=59)and control group(n=59).Both groups were given basic antiglycemic therapy,while the control group was given mecobalamin tablets.On this basis,the observation group was treated with Fuzheng Guben Huayu decoction for foot bath,and the inflammatory factors[nuclear factor-kB(NF-kB),IL-6(IL)]were compared between the two groups.Clinical symptom score,nerve conduction function[motor conduction velocity(MNCV),sensory conduction velocity(SNCV)],hemorheological indexes(fibrinogen,plasma viscosity,red blood cell backlog),and quality of life score were compared.Results After treatment,the levels of NF-kB and IL-6 in the observation group were lower than those in the control group.The limb pain,limb coldness,limb weakness,limb soft numbness,sensory decline,muscle atrophy score and total score in the observation group were lower than those in the control group.The median nerve MNCV and SNCV,common peroneal nerve MNCV and SNCV in the observation group were higher than those in the control group.The fibrinogen,plasma viscosity and red blood cell backlog in the observation group were all lower than those in the control group.Compared with those of the control group,physiological function,mental and psychological,social relationship,treatment score and total score were lower in the observation group,and the difference was statistically significant(P<0.05).Conclusion The foot bath can reduce the levels of inflammatory factors in patients with diabetic peripheral neuropathy,relieve the pain of limbs and other clinical symptoms,and improve nerve conduction function and hemorheology index,and thus improving the quality of life.
作者
陈彩云
张慧丽
李萍
CHEN Caiyun;ZHANG Huili;LI Ping(Zhengzhou Seventh People's Hospital,Zhengzhou 450000,Henan,China)
出处
《实用中医内科杂志》
2020年第7期48-51,共4页
Journal of Practical Traditional Chinese Internal Medicine
基金
河南省科技攻关计划(122102310134)。
关键词
糖尿病周围神经病变
扶正固本化瘀汤足浴
甲钴胺片
神经传导功能
diabetic peripheral neuropathy
Fuzheng Guben Huayu decoction for foot bath
mecobalamin tablets
nerve conduction function
