摘要
目的探讨丹红注射液联合氧化苦参碱治疗冠心病心绞痛的临床价值。方法将2016年9月—2018年12月收治的102例冠心病心绞痛患者,以随机数字表法分为观察组和对照组各51例,两组均给予常规治疗,对照组加用氧化苦参碱,观察组在对照组基础上应用丹红注射液。观察两组治疗效果,治疗前、治疗4周后心绞痛发作情况及心肌缺血总负荷(TIB)、心率变异性(HRV)时域指标、Q-T离散度(QTd)变化,记录不良反应发生情况。结果治疗总有效率观察组为94.12%(48/51),与对照组78.43%(40/51)对比,明显较高(P<0.05);治疗前,两组心绞痛发作情况及TIB、HRV、QTd均无明显差异(P>0.05),治疗4周后,观察组心绞痛发作次数、持续时间与同期对照组对比,明显较少,疼痛程度与同期对照组对比,明显较轻(P<0.05);治疗4周后,观察组TIB、所有正常相邻NN间期标准差(SDNN)、连续5 min正常相邻NN间期平均值的标准差(SDANN)、QTd改善情况明显优于同期对照组(P<0.05);不良反应发生率观察组为15.69%(8/51),与对照组9.80%(5/51)对比,差异无统计学意义(P>0.05)。结论丹红注射液联合氧化苦参碱治疗冠心病心绞痛,疗效确切,能有效抑制心绞痛发作,改善患者TIB、HRV、QTd,且具有较高安全性,值得推广。
Objective To investigate the clinical value of Danhong Injection combined with oxymatrine in the treatment of angina pectoris of coronary disease.Methods A total of 102 patients with angina pectoris of coronary disease admitted from Sep 2016 to Dec 2018 were randomly assigned to a random number table,51 patients in the observation group and 51 patients in the control group.Both groups were given routine treatment.The control group was treated with oxymatrine,and the observation group was treated with Danhong Injection on the basis of the control group.We observed the therapeutic effects,the changes of incidence of angina pectoris,total ischemia burden(TIB),heart rate variability(HRV)time domain index and Q-T dispersion(QTd)of the two groups before and 4 weeks after treatment,and recorded the occurrence of adverse reactions.Results The total effective rate of treatment was 94.12%(48/51)in the observation group,significantly higher than that of the control group 78.43%(40/51)(P<0.05).Before treatment,there was no significant difference in the incidence of angina pectoris,TIB,HRV or QTd between the two groups(P>0.05).After 4 weeks of treatment,the number and duration of angina pectoris in the observation group were significantly less than those of the control group at the same period.The degree of pain was significantly lighter than that of the control group at the same period(P<0.05).After 4 weeks of treatment,the improvement of the TIB,standard deviaton of the NN intervals(SDNN),standard deviaton of the averages of normal NN intervals in all 5-minute segments(SDANN)and QTd in the observation group were significantly better than those of the control group at the same period(P<0.05).The incidence of adverse reactions was 15.69%(8/51)in the observation group and that of the control group was 9.80%(5/51).The difference was not statistically significant(P>0.05).Conclusion Danhong Injection combined with oxymatrine in the treatment of angina pectoris of coronary disease is effective,and can effectively inhibit the onset of angina pectoris and improve TIB,HRV and QTd,and it has high safety,worthy of promotion.
作者
詹正学
蒋世月
李静
HAN Zhengxue;JIANG Shiyue;LI Jing(The Third Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou,China)
出处
《中华中医药学刊》
CAS
北大核心
2020年第7期60-63,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家中医药管理局项目(国中医20150103)。
