摘要
目的分析三维适形放疗(3D-CRT)联合周剂量多西他赛治疗食管癌患者的效果。方法随机抽取2017年1月至2018年1月医院收治的69例食管癌患者,根据治疗方式的不同将其分为观察组(35例)和对照组(34例)。对照组患者接受3D-CRT化疗,观察组在此基础上加用多西他赛周剂量同步化疗,比较两组患者的治疗效果。结果观察组优良率明显高于对照组,差异有统计学意义(P<0.05);治疗3年后,观察组病死率明显低于对照组患者,差异有统计学意义(P<0.05);观察组不良反应总发生率低于对照组,但差异无统计学意义(P>0.05)。结论相较于单独实施3D-CRT,3D-CRT联合多西他赛周剂量对食管癌患者具有良好的治疗效果,并降低患者治疗后的病死率,且不良反应较少。
Objective To analyze the effect of three-dimensional conformal radiotherapy(3D-CRT)combined with weekly dose docetaxel in the treatment of esophageal cancer.Methods From January 2017 to January 2018,69 patients with esophageal cancer admitted to our hospital were randomly selected for retrospective analysis.According to the treatment mode,the patients were divided into observation group and control group.Patients in the control group received 3D-CRT chemotherapy,34 patients in the group.On this basis,the observation group was treated with docetaxel weekly dose synchronous chemotherapy,35 patients in the group.The therapeutic effect of the patients were compared.Results The therapeutic effect of the observation group was significantly better than that of the control group,and the difference was statistically significant(P<0.05).The mortality within 3years after treatment was significantly lower than that of the control group,with statistically significant difference(P<0.05).The total incidence of adverse reactions was lower than the control group,but the difference was not statistically significant(P>0.05).Conclusion Compared with 3D-CRT alone,3D-CRT combined with weekly dose of docetaxel has a good therapeutic effect on esophageal cancer patients,and can reduce the mortality rate of patients after treatment,and the difference between adverse reactions is small.
作者
喻泊遥
YU Boyao(Xiangya Medical College of Central South University,Changsha 410000,China)
出处
《中国医药指南》
2020年第23期35-36,共2页
Guide of China Medicine
关键词
食管癌
三维适形放疗
多西他赛
化疗
不良反应
Esophageal cancer
Three dimensional conformal radiotherapy
Docetaxel
Chemotherapy
Adverse reactions
