摘要
目的:探讨自身免疫性溶血性贫血(AIHA)患者应用不同红细胞输注方式的效果。方法:抽取2019年1月至2020年1月吉林省一汽总医院收治的118例AIHA患者,按照不同输注方式将其分为A、B两组,每组59例。A组输血治疗使用洗涤红细胞进行输注,B组使用去白红细胞输注。观察比较两组治疗后实验室指标、疗效及不良反应发生情况。结果:两组治疗前后血红蛋白、红细胞计数、网织红细胞比例、胆红素水平比较,差异未见统计学意义(P>0.05);治疗后血红蛋白、红细胞计数水平高于治疗前(P<0.05),网织红细胞比例、胆红素水平低于治疗前(P<0.05)。两组有效率比较差异未见统计学意义(P>0.05)。两组输血期间过敏、紫癜、非溶血性发热等不良反应发生率比较,差异未见统计学意义(P>0.05)。结论:洗涤红细胞和去白红细胞输注均可有效缓解AIHA患者临床症状,提高血红蛋白等水平以改善贫血,且两者不良反应无显著差异,但由于去白红细胞价格相对较贵,临床应根据患者身体素质及经济情况选择性治疗。
Objective To investigate the effect of red blood cell infusion by different methods on patients with autoimmune hemolytic anemia(AIHA).Methods A total of 118 patients with AIHI in FAW General Hospital of Jilin from January 2019 to January 2020 were enrolled,and they were divided into two groups according to different infusion methods,with 59 cases in each group.Group A was infused with washed red blood cell(RBC),while group B was infused with washed white blood cell(WBC)-depleted RBC.Then the laboratory indexes,curative effect and adverse reactions were compared between the two groups.Results There two no differences in hemoglobin,RBC count,reticulocyte proportion and bilirubin level between the two groups before and after treatment(P>0.05),after treatment,hemoglobin and RBC count increased(P<0.05),while reticulocyte proportion and bilirubin level decreased(P<0.05).There was no difference in clinical efficacy between the two groups(P>0.05).The incidence of anaphylaxis,purpura,non hemolytic fever and other adverse reactions were compared between the two groups,the differences were not significant(P>0.05).Conclusions Both washed RBC and WBC-depleted RBC are effective for AIHI patients,which can effectively improve level of hemoglobin,and the incidence rate of adverse reaction has no difference between the two methods,while the cost of WBC-depleted RBC is relatively high,so the clinical treatment should be based on the patient's condition.
作者
李明
邓卫
Li Ming;Deng Wei(Department of Blood Transfusion,FAW General Hospital of Jilin,Changchun 130011,China;Department of Endocrinology,FAW General Hospital of Jilin,Changchun 130011,China)
出处
《中国实用医刊》
2020年第12期66-68,共3页
Chinese Journal of Practical Medicine
关键词
红细胞输注
自身免疫性溶血性贫血
输血
Red blood cell infusion
Autoimmune hemolytic anemia
Blood transfusion
