摘要
目的探讨体质量指数、血脂、血清瘦素及脂联素与甲状腺乳头状癌发生的关系。方法选取2015年4月至2016年1月内蒙古自治区人民医院甲状腺乳头状癌患者40例(甲状腺乳头状癌组)、结节性甲状腺肿患者40例(结节性甲状腺肿组)及同期体检无甲状腺疾病及其他代谢性疾病者40例(对照组),计算所有受试者体质量指数并检测血脂、瘦素和脂联素水平。结果结节性甲状腺肿组和甲状腺乳头状癌组女性多于男性,三组间性别分布差异有统计学意义(χ^2=19.024,P<0.01)。甲状腺乳头状癌组体质量指数、瘦素、三酰甘油、总胆固醇水平[(24.86±3.26)kg/m2、(0.68±0.07)ng/ml、(1.42±0.53)mmol/L、(4.76±0.57)mmol/L]均高于对照组[(20.79±2.15)kg/m^2、(0.61±0.39)ng/ml、(1.05±0.36)mmol/L、(4.28±0.46)mmol/L],差异均有统计学意义(t值分别为4.302、3.296、1.993、2.177,均P<0.05);结节性甲状腺肿组总胆固醇、低密度脂蛋白水平[(4.97±0.55)mmol/L、(2.72±0.58)mmol/L]均高于对照组[(4.28±0.46)mmol/L、(2.18±0.69)mmol/L],差异均有统计学意义(t值分别为2.954、2.148,均P<0.05);甲状腺乳头状癌组及结节性甲状腺肿组脂联素水平[(4.21±0.34)ng/ml、(4.30±0.27)ng/ml]均低于对照组[(4.87±0.27)ng/ml],差异均有统计学意义(t值分别为7.631、7.416,均P<0.01)。结论体质量指数、三酰甘油、总胆固醇、血清瘦素的升高及血清脂联素的降低可能与甲状腺乳头状癌的发生相关。
Objective To investigate the association of body mass index(BMI),blood lipid,serum leptin,adiponectin with papillary thyroid carcinoma.Methods A total of 120 patients including 40 cases of papillary thyroid carcinoma(papillary thyroid carcinoma group),40 cases of nodular goiter(nodular goiter group)and 40 cases diagnosed without thyroid diseases or other metabolic diseases during the corresponding period(the control group)in Inner Mongolia People's Hospital from April 2015 to January 2016 were enrolled.The BMI of all subjects was calculated.The levels of blood lipid,serum leptin and adiponectin were detected.Results The number of females was more than that of males in nodular goiter group and papillary thyroid carcinoma group,and the difference in gender distribution of three groups was statistically significant(χ^2=19.024,P<0.01).The level of BMI,leptin,triglyceride and total cholesterol of papillary thyroid carcinoma group was higher than that of the control group[(24.86±3.26)kg/m2 vs.(20.79±2.15)kg/m2,(0.68±0.07)ng/ml vs.(0.61±0.39)ng/ml,(1.42±0.53)mmol/L vs.(1.05±0.36)mmol/L,(4.76±0.57)mmol/L vs.(4.28±0.46)mmol/L],and the differences were statistically significant(t values were 4.302,3.296,1.993 and 2.177,respectively,all P<0.05).The level of total cholesterol and low-density lipoprotein[(4.97±0.55)mmol/L,(2.72±0.58)mmol/L]in the nodular goiter group was higher than that in the control group[(4.28±0.46)mmol/L,(2.18±0.69)mmol/L],and the differences were statistically significant(t values were 2.954 and 2.148,respectively;all P<0.05).The level of adiponectin[(4.21±0.34)ng/ml,(4.30±0.27)ng/ml]in papillary thyroid carcinoma and nodular goiter group was lower than that in the control group[(4.87±0.27)ng/ml],and the differences were statistically significant(t values were 7.631 and 7.416,respectively;all P<0.05).Conclusion The increase of BMI,triglyceride,total cholesterol,serum leptin and the decrease of serum adiponectin may be related to the occurrence of papillary thyroid carcinoma.
作者
王欢
李杨
娄婷婷
庞向鹏
李燕
迟卉
马翠翠
郭瑞芳
刘亚航
Wang Huan;Li Yang;Lou Tingting;Pang Xiangpeng;Li Yan;Chi Hui;Ma Cuicui;Guo Ruifang;Liu Yahang(Clinical Nutrition Center,the People's Hospital of Inner Mongolia Autonomous Region,Huhhot 010017,China;Department of Gastroenterology,Affiliated Hospital of Inner Mongolia University for the Nationalities,Tongliao 028000,China;Postgraduate College,Inner Mongolia Medical University,Huhhot 010110,China;Department of Thyroid Tumor Surgery,the People's Hospital of Inner Mongolia Autonomous Region,Huhhot 010017,China)
出处
《肿瘤研究与临床》
CAS
2020年第7期481-484,共4页
Cancer Research and Clinic
基金
内蒙古自治区科技计划(201602097)
内蒙古自治区自然科学基金(2016MS0870)
内蒙古自治区人民医院科研基金(201502)。
