摘要
肝细胞癌(HCC)是常见的恶性肿瘤之一,进展快且预后差,其发病机制异常复杂,涉及基因突变、信号通路异常激活及表观遗传学改变等多个方面。自噬作为细胞应激时维持内环境稳定、促进细胞存活的基本生理现象,在多种肿瘤的发生、发展及预后等方面都发挥重要作用,在HCC中也不例外,自噬可通过上述分子机制参与HCC的发生发展。现就近年来自噬与HCC关系的研究进展进行综述。
Hepatocellular carcinoma(HCC)is one of the most common malignant tumors with quick disease progression and poor prognosis.The pathogenesis is extremely complex,involving genetic mutations,abnormal activation of signal pathways,and epigenetic changes.Autophagy is a basic physiological phenomenon of maintaining internal environment stability and promoting cell survival when cell stress occurs,which plays an important role in the occurrence,development and prognosis of various tumors including HCC.Autophagy can participate in the formation and progress of HCC through the above molecular mechanisms.This paper reviews the progress of relationship between autophagy and HCC.
作者
朱博兰
杨晓娟
张裕
惠玲
于晓辉
Zhu Bolan;Yang Xiaojuan;Zhang Yu;Hui Ling;Yu Xiaohui(Department of Gastroenterology,the 940 Hospital of Joint Logistic Support Force of PLA,Lanzhou 730050,China;Graduate School,Gansu University of Chinese Medicine,Lanzhou 730000,China;Key Laboratory of Stem Cells and Gene Drugs of Gansu Province,Lanzhou 730050,China)
出处
《肿瘤研究与临床》
CAS
2020年第7期521-524,共4页
Cancer Research and Clinic
基金
甘肃省科技支撑项目(1604FKCA101)。
关键词
自噬
癌
肝细胞
信号传导
表观基因组
Autophagy
Carcinoma
hepatocellular
Signal transduction
Epigenomics
